DYRK2
DYRK2 is a nuclear DYRK-family kinase with an established role in genome-stability signaling. Upon DNA damage it phosphorylates p53 at Ser46, a modification that drives pro-apoptotic gene expression, and it also phosphorylates the substrate-recognition protein SPOP to control turnover of targets such as c-Myc and c-Jun. DYRK2 associates with complexes implicated in meiotic chromosome dynamics and DNA repair, and its own stability is regulated in a damage-dependent manner. Expression is broad but modest compared with DYRK1A, and reduced DYRK2 activity has been linked to chemoresistance. Recombinant DYRK2 enables p53-pathway studies, substrate validation, and screening of DYRK-family inhibitors.
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DYRK2 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
