DYRK2 Protein, Human (GST)

DYRK2 is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including the mitotic cell cycle, cell proliferation, apoptosis, cytoskeletal organization, and neurite outgrowth. DYRK2 operates downstream of ATM to phosphorylate p53/TP53 at the “Ser-46” site, leading to DNA damage-induced apoptosis. DYRK2 Protein, Human (GST) is the recombinant human-derived DYRK2 protein, expressed by E. coli , with N-GST labeled tag. The total length of DYRK2 Protein, Human (GST) is 600 a.a., .

DYRK2, a serine/threonine-protein kinase, intricately regulates diverse cellular processes, including the mitotic cell cycle, cell proliferation, apoptosis, cytoskeleton organization, and neurite outgrowth. Operating partially through its involvement in ubiquitin-dependent proteasomal protein degradation, DYRK2 functions downstream of ATM, phosphorylating p53/TP53 at 'Ser-46' to contribute to DNA damage-induced apoptosis. Additionally, DYRK2 exerts its influence on multiple substrates, including NFATC1, EIF2B5, CRMP2/DPYSL2, CRMP4/DPYSL3, and more, impacting various signaling pathways and cellular functions. By participating in the phosphorylation and subsequent degradation of key regulators like MYC, JUN, GLI2, and GLI3, DYRK2 finely tunes the progression through the mitotic cell cycle and cell proliferation. Notably, its role in cytoskeleton organization and neurite outgrowth is manifested through the phosphorylation of DCX and DPYSL2. The multifaceted kinase DYRK2 emerges as a central player in the orchestration of crucial cellular processes through its precise modulation of diverse substrates.

Human

E. coli

N-GST

Q92630 (L2-S601)

8445

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.