2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. DYRKs-IN-1

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (DYRKs-IN-1 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

DYRKs-IN-1 Chemical Structure

DYRKs-IN-1 Chemical Structure

CAS No. : 1387090-01-8

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DYRKs-IN-1 Related Antibodies

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Description

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity[1][2].

IC50 & Target[1]

DYRK1A

5 nM (IC50)

DYRK1B

8 nM (IC50)

In Vitro

DYRKs-IN-1 (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1].
DYRKs-IN-1 (Example 183) is a potent DYRKs inhibitor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DYRKs-IN-1 Related Antibodies
Molecular Weight

588.06

Formula

C30H30ClN7O4
CAS No.
SMILES

O=C(C1=CC2=CN=C(N3CC(O4)CCC4C3)N=C2NC1=O)NC5=CC(C(NC(C6=CC=CC=C6)CCN)=O)=CC=C5Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DYRKs-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYRKs-IN-11387090-01-8DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasecolontumorSW620Inhibitorinhibitorinhibit

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