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Cat. No.: HY-128758

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DYRKs-IN-1

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC₅₀s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 1387090-01-8
Formula: C₃₀H₃₀ClN₇O₄
Molecular Weight:588.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DYRKs-IN-1 Chemical Structure

CAS No.: 1387090-01-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

DYRK1A

5 nM (IC₅₀)

DYRK1B

8 nM (IC₅₀)

All DYRK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SW-620	EC₅₀	0.027 μM Compound: 30	Cytotoxicity against human SW620 cells Cytotoxicity against human SW620 cells	[PMID: 24239188]

In Vitro

DYRKs-IN-1 (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC₅₀ of 27 nM^[1].
DYRKs-IN-1 (Example 183) is a potent DYRKs inhibitor^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1387090-01-8
Molecular Weight 588.06
Formula C₃₀H₃₀ClN₇O₄
SMILES

O=C(C1=CC2=CN=C(N3CC(O4)CCC4C3)N=C2NC1=O)NC5=CC(C(NC(C6=CC=CC=C6)CCN)=O)=CC=C5Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5. [Content Brief]

[2]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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