1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. DYRKs-IN-1

DYRKs-IN-1 

Cat. No.: HY-128758
Handling Instructions

DYRKs-IN-1 (Example 183) is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-1 has antitumor activity.

For research use only. We do not sell to patients.

DYRKs-IN-1 Chemical Structure

DYRKs-IN-1 Chemical Structure

CAS No. : 1387090-01-8

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Description

DYRKs-IN-1 (Example 183) is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-1 has antitumor activity[1][2].

IC50 & Target

IC50: 9 nM (DYRK1B) and 5 nM (DYRK1A)[2]

In Vitro

DYRKs-IN-1 (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[2].

Molecular Weight

588.06

Formula

C₃₀H₃₀ClN₇O₄

CAS No.

1387090-01-8

SMILES

O=C(C1=CC2=CN=C(N3CC(O4)CCC4C3)N=C2NC1=O)NC5=CC(C(NC(C6=CC=CC=C6)CCN)=O)=CC=C5Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DYRKs-IN-1DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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DYRKs-IN-1
Cat. No.:
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