1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. DYRKs-IN-1

DYRKs-IN-1 

Cat. No.: HY-128758
Handling Instructions

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity.

For research use only. We do not sell to patients.

DYRKs-IN-1 Chemical Structure

DYRKs-IN-1 Chemical Structure

CAS No. : 1387090-01-8

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Description

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity[1][2].

IC50 & Target[1]

DYRK1A

5 nM (IC50)

DYRK1B

8 nM (IC50)

In Vitro

DYRKs-IN-1 (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1].
DYRKs-IN-1 (Example 183) is a potent DYRKs inhibitor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

588.06

Formula

C₃₀H₃₀ClN₇O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
DYRKs-IN-1
Cat. No.:
HY-128758
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