1. Cell Cycle/DNA Damage
  2. CDK
  3. ML167

ML167 (Synonyms: CID44968231; NCGC00188654)

Cat. No.: HY-15951 Purity: 98.51%
Handling Instructions

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B.

For research use only. We do not sell to patients.

ML167 Chemical Structure

ML167 Chemical Structure

CAS No. : 1285702-20-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
25 mg USD 276 In-stock
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B.

IC50 & Target[1]

Clk4

136 nM (IC50)

CLK1

1522 nM (IC50)

CLK2

1648 nM (IC50)

Dyrk1B

4420 nM (IC50)

Molecular Weight

335.36

Formula

C₁₉H₁₇N₃O₃

CAS No.

1285702-20-6

SMILES

OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (49.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9819 mL 14.9094 mL 29.8187 mL
5 mM 0.5964 mL 2.9819 mL 5.9637 mL
10 mM 0.2982 mL 1.4909 mL 2.9819 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

ML167CID44968231NCGC00188654ML 167ML-167CID 44968231CID-44968231NCGC 00188654NCGC-00188654CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
ML167
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HY-15951
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