1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. AZ191

AZ191 

Cat. No.: HY-12277 Purity: 99.98%
Handling Instructions

AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.

For research use only. We do not sell to patients.

AZ191 Chemical Structure

AZ191 Chemical Structure

CAS No. : 1594092-37-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 528 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM[1].

IC50 & Target

IC50: 17 nM (DYRK1B)[1]

In Vitro

AZ191 (0.01-60μM; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC50s of 3.183 μM and 1.279 μM, respectively[2].
AZ191 (1-5 μM; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations[2].

Cell Proliferation Assay[2]

Cell Line: SW872, SW982 liposarcoma cells
Concentration: 0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μM
Incubation Time: 5 days
Result: Dose-dependent growth inhibition with IC50s of 3.183 μM and 1.279 μM for SW872 and SW982 cell lines, respectively.

Western Blot Analysis[2]

Cell Line: SW872, SW982 liposarcoma cells
Concentration: 1, 2, 3, 4, 5 μM
Incubation Time: 48 hours
Result: Down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.
Molecular Weight

429.52

Formula

C₂₄H₂₇N₇O

CAS No.

1594092-37-1

SMILES

CN1C2=CN=CC=C2C(C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (69.85 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3282 mL 11.6409 mL 23.2818 mL
5 mM 0.4656 mL 2.3282 mL 4.6564 mL
10 mM 0.2328 mL 1.1641 mL 2.3282 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.82 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.98%

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Product Name:
AZ191
Cat. No.:
HY-12277
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