1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. AZ-Dyrk1B-33

AZ-Dyrk1B-33 

Cat. No.: HY-117391 Purity: 99.95%
Handling Instructions

AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM.

For research use only. We do not sell to patients.

AZ-Dyrk1B-33 Chemical Structure

AZ-Dyrk1B-33 Chemical Structure

CAS No. : 1679330-37-0

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Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1790 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].

IC50 & Target

IC50: 7 nM (Dyrk1B)[1]

In Vitro

AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM[1].
AZ-Dyrk1B-33 shows no effect in sensitization[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

300.36

Formula

C19H16N4

CAS No.
SMILES

CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=C2C=CN=C4)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (416.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3293 mL 16.6467 mL 33.2934 mL
5 mM 0.6659 mL 3.3293 mL 6.6587 mL
10 mM 0.3329 mL 1.6647 mL 3.3293 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.95%

References
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Product Name:
AZ-Dyrk1B-33
Cat. No.:
HY-117391
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