Anti-IAV agent 1

Cat. No.: HY-151967: FAQs
Data Sheet Handling Instructions

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Anti-IAV agent 1 (Compound (R)-1a) is an orally active anti-influenza A virus (IAV) agent with IC₅₀s of 0.03 and 0.06 μM against IAV H1N1 and Oseltamivir-resistant IAV H1N1 strains, respectively.

For research use only. We do not sell to patients.

Anti-IAV agent 1 Chemical Structure

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Description

In Vivo

Anti-IAV agent 1 (Compound (R)-1a) (1.67-15 mg/kg; p.o.; twice daily for 7 days) shows anti-IAV activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Kunming Mice lethal challenge model with H1N1 A/Puerto Rico/8/1934 virus^[1]
Dosage:	1.67, 5 and 15 mg/kg
Administration:	Oral administration, twice daily for 7 days
Result:	Improved the survival rate.

Animal Model:

Balb/c mice^[1]

Dosage:

25 mg/kg

Administration:

Oral administration (Pharmacokinetic Analysis)

Result:

PK property in Balb/c mice after a single oral administration of 25 mg/kg, n = 3.

Compd.	T_1/2 (h)	T_max (h)	C_max (ng/mL)	AUC_0-inf (ng⋅h/mL)	^ahERG IR (n = 3)
Anti-IAV agent 1 (Compound (R)-1a)	5.84 ± 0.63	0.33 ± 0	866 ± 205	1913 ± 554	13.2 ± 2.87%

^ahERG ion channel inhibition rate at 10 μM, n = 3. Abbreviations: T_1/2, elimination half-life; T_max, the time at which the C_max is observed; C_max, the maximum serum concentration; AUC_0-inf, area under the concentration-time curve up to infinite time; hERG, human Ether-a-gogo related gene.

Molecular Weight

557.58

Formula

C₂₈H₂₈FN₉O₃

SMILES

CC(NC1=CC2N=C(OC2C=C1)C3=CC(C(N4CCN(CC4)[C@@H](C5=NN(C)N=N5)C6=CC=C(C=C6)F)=O)=NC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu W, et al. Optimization and SAR research at the benzoxazole and tetrazole rings of JNJ4796 as new anti-influenza A virus agents, part 2. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114906. [Content Brief]

Anti-IAV agent 1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-IAV agent 1Influenza VirusIAVH1N1Kunming MiceA/Puerto Rico/8/1934Inhibitorinhibitorinhibit

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