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Cat. No.: HY-151967

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Anti-IAV agent 1

Anti-IAV agent 1 (Compound (R)-1a) is an orally active anti-influenza A virus (IAV) agent with IC₅₀s of 0.03 and 0.06 μM against IAV H1N1 and Oseltamivir-resistant IAV H1N1 strains, respectively.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₈FN₉O₃
Molecular Weight:557.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Anti-IAV agent 1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Anti-IAV agent 1 (Compound (R)-1a) (1.67-15 mg/kg; p.o.; twice daily for 7 days) shows anti-IAV activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming Mice lethal challenge model with H1N1 A/Puerto Rico/8/1934 virus^[1]
Dosage:

1.67, 5 and 15 mg/kg
Administration:

Oral administration, twice daily for 7 days
Result:

Improved the survival rate.

Animal Model:

Balb/c mice^[1]
Dosage:

25 mg/kg
Administration:

Oral administration (Pharmacokinetic Analysis)

Result:

PK property in Balb/c mice after a single oral administration of 25 mg/kg, n = 3.

Compd.	T_1/2 (h)	T_max (h)	C_max (ng/mL)	AUC_0-inf (ng⋅h/mL)	^ahERG IR (n = 3)
Anti-IAV agent 1 (Compound (R)-1a)	5.84 ± 0.63	0.33 ± 0	866 ± 205	1913 ± 554	13.2 ± 2.87%

^ahERG ion channel inhibition rate at 10 μM, n = 3. Abbreviations: T_1/2, elimination half-life; T_max, the time at which the C_max is observed; C_max, the maximum serum concentration; AUC_0-inf, area under the concentration-time curve up to infinite time; hERG, human Ether-a-gogo related gene.

Chemical Information

Molecular Weight 557.58
Formula C₂₈H₂₈FN₉O₃
SMILES

CC(NC1=CC2N=C(OC2C=C1)C3=CC(C(N4CCN(CC4)[C@@H](C5=NN(C)N=N5)C6=CC=C(C=C6)F)=O)=NC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu W, et al. Optimization and SAR research at the benzoxazole and tetrazole rings of JNJ4796 as new anti-influenza A virus agents, part 2. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114906. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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