2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. ProTx-III

ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia.

For research use only. We do not sell to patients.

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ProTx-III Chemical Structure

ProTx-III Chemical Structure

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ProTx-III Related Antibodies

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Description

ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia[1].

IC50 & Target

Nav1.7

2.1 nM (IC50)

In Vitro

ProTx-III in native, recombinant and synthetic C-terminal acid and amide forms inhibit hNaV1.7 with IC50s of 2.1, 9.5, 11.5 and 2.5 nM, respectively[1].
. ProTx-III inhibits hNav1.7 without significantly altering the voltage dependence of activation or inactivation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ProTx-III Related Antibodies
In Vivo

ProTx-III (0.01-1 μM; intraplantar injection) can proves to be analgesic by reversing spontaneous pain induces in mice by intraplantar injection in OD1 in mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OD1-induced mouse model of pain(300Nm; intraplantar injection)[1]
Dosage: 100 nM, 300 nM, 1μM
Administration: intraplantar injection
Result: Showed at 1 μM (40 pmoles in a 40 μl injection) and 300 nM (12 pmoles in a 40 μl injection) significantly reduced spontaneous pain behaviour in a concentration dependent manner and this reduction in pain behaviour persisted for 25 min after injection of the highest concentration.
Molecular Weight

3802.40

Formula

C162H246N52O43S6
Sequence

Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
Sequence Shortening

DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ProTx-III Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ProTx-IIIμ-TRTX-Tp1aSodium ChannelNa channelsNa+ channelschronic painTp1aepilepsyarrhythmiapeptide toxinsInhibitorinhibitorinhibit

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