DDP-38003 dihydrochloride

Cat. No.: HY-19612A Purity: 98.22%: FAQs
Data Sheet SDS COA Handling Instructions

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DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM.

For research use only. We do not sell to patients.

DDP-38003 dihydrochloride Chemical Structure

CAS No. : 1831167-98-6

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1900	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of DDP-38003 dihydrochloride:

DDP-38003 trihydrochloride Get quote

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Description

DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM^[1].

IC₅₀ & Target

IC50: 84 nM (KDM1A/LSD1)^[1]

In Vitro

DDP-38003 inhibits KDM1A with an IC₅₀ of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

423.38

Formula

C₂₁H₂₈Cl₂N₄O

CAS No.

1831167-98-6

Appearance

Solid

Color

Brown to reddish brown

SMILES

[H]Cl.O=C(NC1=CC=C([C@@H]2C[C@H]2N)C=C1)C(C=C3)=CC=C3N4CCN(C)CC4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 29 mg/mL (68.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3619 mL	11.8097 mL	23.6194 mL
5 mM	0.4724 mL	2.3619 mL	4.7239 mL
10 mM	0.2362 mL	1.1810 mL	2.3619 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.22%

Select Batch:

Data Sheet (245 KB) SDS (0 KB)

COA (246 KB) RP-HPLC (206 KB)

Handling Instructions (2659 KB)

Animal Administration
^[1]

Mice: CD-1 mice is used in the study. DDP-38003 is dissolved (40% PEG 400 in a 5% glucose solution) and orally administered 3 days per week (Monday, Tuesday and Wednesday) for 3 weeks at the doses of 11.25 mg/kg and 22.5 mg/kg. The treatment started once blast cells are detected in the recipients' peripheral blood (10 days after cell injection). The survival of mice of the different experimental groups is analyzed and represented by a Kaplan-Meier survival plot^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3619 mL	11.8097 mL	23.6194 mL	59.0486 mL
	5 mM	0.4724 mL	2.3619 mL	4.7239 mL	11.8097 mL
	10 mM	0.2362 mL	1.1810 mL	2.3619 mL	5.9049 mL
	15 mM	0.1575 mL	0.7873 mL	1.5746 mL	3.9366 mL
	20 mM	0.1181 mL	0.5905 mL	1.1810 mL	2.9524 mL
	25 mM	0.0945 mL	0.4724 mL	0.9448 mL	2.3619 mL
	30 mM	0.0787 mL	0.3937 mL	0.7873 mL	1.9683 mL
	40 mM	0.0590 mL	0.2952 mL	0.5905 mL	1.4762 mL
	50 mM	0.0472 mL	0.2362 mL	0.4724 mL	1.1810 mL
	60 mM	0.0394 mL	0.1968 mL	0.3937 mL	0.9841 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDP-380031831167-98-6DDP38003DDP 38003Inhibitorinhibitorinhibit

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DDP-38003 dihydrochloride

Other Forms of DDP-38003 dihydrochloride: