1. Epigenetics
  2. Histone Demethylase
  3. Seclidemstat

Seclidemstat (Synonyms: SP-2577)

Cat. No.: HY-103713 Purity: 98.78%
Handling Instructions

Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.

For research use only. We do not sell to patients.

Seclidemstat Chemical Structure

Seclidemstat Chemical Structure

CAS No. : 1423715-37-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 327 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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Description

Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.

IC50 & Target

IC50: 127 nM (LSD1)[1]

In Vivo

Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (221.76 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2176 mL 11.0879 mL 22.1759 mL
5 mM 0.4435 mL 2.2176 mL 4.4352 mL
10 mM 0.2218 mL 1.1088 mL 2.2176 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

450.94

Formula

C₂₀H₂₃ClN₄O₄S

CAS No.

1423715-37-0

SMILES

O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCN(C)CC3)=O)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.78%

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Seclidemstat
Cat. No.:
HY-103713
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Seclidemstat

Cat. No.: HY-103713