2. Epigenetics
  3. Histone Demethylase
  4. Seclidemstat mesylate

Seclidemstat mesylate  (Synonyms: SP-2577 mesylate)

Cat. No.: HY-103713A Purity: 99.86%
COA Handling Instructions

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Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma.

For research use only. We do not sell to patients.

Seclidemstat mesylate Chemical Structure

Seclidemstat mesylate Chemical Structure

CAS No. : 2044953-70-8

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Based on 4 publication(s) in Google Scholar

Other Forms of Seclidemstat mesylate:

Seclidemstat mesylate Related Antibodies

Top Publications Citing Use of Products

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

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Description

Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma[1][2].

IC50 & Target

Ki: 31 nM (LSD1)[1]
IC50: 13 nM (LSD1)[1]
In Vitro

Seclidemstat (72 hours) mesylate inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 ranging from 0.013 to 2.819 μM (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15 cells)[2].
Seclidemstat (72 hours) mesylate promotes endogenous retroviruses (ERVs) expression and activation of IFNβ pathway in SCCOHT cell lines (SCCOHT-1, BIN67, and COV434 cells)[2].
Seclidemstat (3 μM) mesylate promotes PD-L1 expression in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Seclidemstat mesylate Related Antibodies
Clinical Trial
Molecular Weight

547.04

Formula

C21H27ClN4O7S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCN(C)CC3)=O)=C2.CS(O)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 53.33 mg/mL (97.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8280 mL 9.1401 mL 18.2802 mL
5 mM 0.3656 mL 1.8280 mL 3.6560 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.86%

COA (249 KB) HNMR (237 KB) LCMS (143 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8280 mL 9.1401 mL 18.2802 mL 45.7005 mL
5 mM 0.3656 mL 1.8280 mL 3.6560 mL 9.1401 mL
10 mM 0.1828 mL 0.9140 mL 1.8280 mL 4.5700 mL
15 mM 0.1219 mL 0.6093 mL 1.2187 mL 3.0467 mL
20 mM 0.0914 mL 0.4570 mL 0.9140 mL 2.2850 mL
25 mM 0.0731 mL 0.3656 mL 0.7312 mL 1.8280 mL
30 mM 0.0609 mL 0.3047 mL 0.6093 mL 1.5233 mL
40 mM 0.0457 mL 0.2285 mL 0.4570 mL 1.1425 mL
50 mM 0.0366 mL 0.1828 mL 0.3656 mL 0.9140 mL
60 mM 0.0305 mL 0.1523 mL 0.3047 mL 0.7617 mL
80 mM 0.0229 mL 0.1143 mL 0.2285 mL 0.5713 mL
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Seclidemstat mesylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seclidemstat2044953-70-8SP-2577SP2577SP 2577Histone DemethylasereversibleantitumorimmunitySWI/SNFcomplexDNAreplicationEwingSarcomaInhibitorinhibitorinhibit

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