1. Epigenetics
  2. Histone Demethylase

AS8351 

Cat. No.: HY-100744 Purity: 99.70%
Data Sheet SDS Handling Instructions

AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.

For research use only. We do not sell to patients.
AS8351 Chemical Structure

AS8351 Chemical Structure

CAS No. : 796-42-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $70 In-stock
50 mg $270 In-stock
100 mg $490 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Featured Recommendations

Related Screening Libraries:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.

IC50 & Target

KDM5B[1]

In Vitro

AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.4329 mL 17.1644 mL 34.3289 mL
5 mM 0.6866 mL 3.4329 mL 6.8658 mL
10 mM 0.3433 mL 1.7164 mL 3.4329 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

291.3

Formula

C₁₇H₁₃N₃O₂

CAS No.

796-42-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 150 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AS8351
Cat. No.:
HY-100744
Quantity: