1. Epigenetics
  2. Histone Demethylase

AS8351 

Cat. No.: HY-100744 Purity: 99.70%
Handling Instructions

AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.

For research use only. We do not sell to patients.

AS8351 Chemical Structure

AS8351 Chemical Structure

CAS No. : 796-42-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 324 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 588 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells.

IC50 & Target

KDM5B[1]

In Vitro

AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.4329 mL 17.1644 mL 34.3289 mL
5 mM 0.6866 mL 3.4329 mL 6.8658 mL
10 mM 0.3433 mL 1.7164 mL 3.4329 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

291.3

Formula

C₁₇H₁₃N₃O₂

CAS No.

796-42-9

SMILES

O=C(C1=CC=NC=C1)N/N=C/C2=C3C=CC=CC3=CC=C2O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 150 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AS8351
Cat. No.:
HY-100744
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