1. Epigenetics
  2. Histone Demethylase
  3. LSD1-IN-7 benzenesulfonate

LSD1-IN-7 benzenesulfonate 

Cat. No.: HY-129388B Purity: 99.39%
Handling Instructions

LSD1-IN-7 benzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity extracted from patent WO2017079670A1, compound 4-[2-(4-amino-piperidin-1-yl)-5-(3-fluoro-4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-4-yl]-2-fluorobenzonitrile.

For research use only. We do not sell to patients.

LSD1-IN-7 benzenesulfonate Chemical Structure

LSD1-IN-7 benzenesulfonate Chemical Structure

CAS No. : 2097523-60-7

Size Price Stock Quantity
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

LSD1-IN-7 benzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity extracted from patent WO2017079670A1, compound 4-[2-(4-amino-piperidin-1-yl)-5-(3-fluoro-4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-4-yl]-2-fluorobenzonitrile[1].

IC50 & Target

Lysine specific demethylase-1 (LSD1)[1]

In Vivo

LSD1-IN-7 in combination with other LSD1 inhibitor can be treatment of cancer in a mammal, including breast cancer, lung cancer, prostate cancer, glioblastoma, or leukemia[1].

Molecular Weight

609.64

Formula

C₃₀H₂₉F₂N₅O₅S

CAS No.

2097523-60-7

SMILES

N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.O=S(C5=CC=CC=C5)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (102.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6403 mL 8.2016 mL 16.4031 mL
5 mM 0.3281 mL 1.6403 mL 3.2806 mL
10 mM 0.1640 mL 0.8202 mL 1.6403 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LSD1-IN-7Histone DemethylaseLSD1orallyanticancerInhibitorinhibitorinhibit

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Product Name:
LSD1-IN-7 benzenesulfonate
Cat. No.:
HY-129388B
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