2097523-60-7
Chemical Structure
Pulrodemstat benzenesulfonate
Synonym(s): CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate
- CAS No.: 2097523-60-7
- Formula:C30H29F2N5O5S
- Molecular Weight:609.64
IUPAC Name: 4-(2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile benzenesulfonate
InChIKey: AWZCBGWZNHQCIZ-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.O=S(C5=CC=CC=C5)(O)=O
Biological Activity: Pulrodemstat (CC-90011) benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. Pulrodemstat benzenesulfonate is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pulrodemstat benzenesulfonate | 99.64% | Pulrodemstat (CC-90011) benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. Pulrodemstat benzenesulfonate is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity. | ||||||||||||||||||||
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Keywords
