1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Cell Cycle/DNA Damage
  2. p38 MAPK
    Casein Kinase
  3. AMG-548

AMG-548 

Cat. No.: HY-108642 Purity: >99.0% ee.: 100%
Handling Instructions

AMG-548 is a potent, oral and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γand p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) . AMG-548 inhibits Wnt signaling by direcly inhibing Casein kinase 1 isoforms δ and ε.

For research use only. We do not sell to patients.

AMG-548 Chemical Structure

AMG-548 Chemical Structure

CAS No. : 864249-60-5

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Description

AMG-548 is a potent, oral and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γand p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 inhibits Wnt signaling by direcly inhibing Casein kinase 1 isoforms δ and ε[2].

IC50 & Target[1,2]

p38α

0.5 nM (Ki)

p38β

3.6 nM (Ki)

CK1

 

In Vivo

AMG-548 has rat F of 62% and dog F of 47%. The t1/2 is 4.6 hours in rats and 7.3 hours in dogs[1].

Molecular Weight

461.56

Formula

C₂₉H₂₇N₅O

CAS No.

864249-60-5

SMILES

O=C1N(C)C(NC[[email protected]@H](N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0% ee.: 100%

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AMG-548
Cat. No.:
HY-108642
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