1. Epigenetics
  2. Histone Demethylase
  3. IOX1

IOX1 

Cat. No.: HY-12304 Purity: 97.04%
Handling Instructions

IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.

For research use only. We do not sell to patients.

IOX1 Chemical Structure

IOX1 Chemical Structure

CAS No. : 5852-78-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM. IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1] Target: JmjC KDMs inhibitor IOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from its polar C-5 carboxyl group.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 13.33 mg/mL (70.47 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2863 mL 26.4313 mL 52.8625 mL
5 mM 1.0573 mL 5.2863 mL 10.5725 mL
10 mM 0.5286 mL 2.6431 mL 5.2863 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

189.17

Formula

C₁₀H₇NO₃

CAS No.

5852-78-8

SMILES

O=C(C1=C2C=CC=NC2=C(O)C=C1)O

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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IOX1
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IOX1

Cat. No.: HY-12304