Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-17F. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can neutralize IL-17. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can be used for the researches of cancer, infection and neurological disease, such as Alzheimer’s disease (AD) and pancreatic cancer^[1][2][3].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

Mouse

IL-17F

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (200 μg for the first day and 100 μg every other day thereafter, i.p., 3 weeks) restores neurodegenerative microglia response and cognition in Alzheimer’s disease mice ^[1].
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (400 μg, i.p., every 3-4 days until 6 weeks) reduces disease burden and pathological fibrosis in pancreatic cancer mice models^[2].
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (200 μg at days −1 and 100 μg every other day thereafter, i.p.) shows anti-infection effect companied with anti-IL-17A (HY-P990222) in S. aureus infected mice models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

257630  [NCBI]

Q7TNI7-1

in vivo IL-17F neutralization

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rosenzweig N, et al. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease. Nat Med. 2024 Oct;30(10):2990-3003.  [Content Brief]

  [2]. Hegde S, et al. Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer. Cancer Cell. 2020 Mar 16;37(3):289-307.e9.  [Content Brief]

  [3]. Marchitto MC, et al. Clonal Vγ6+Vδ4+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10917-10926.  [Content Brief]