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Mouse IgG1 kappa, Isotype Control

8 Cited Publications
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Based on 8 publication(s) in Google Scholar

Mouse IgG1 kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG1κ antibodies. Mouse IgG1 kappa, Isotype Control, by maintaining the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG1κ subtype primary antibody, eliminates false positive signals caused by non-specific binding in immunological experiments, thus playing a core role in verifying the specificity of the experiment. Mouse IgG1 kappa, Isotype Control can be applied to immunolocalization experiments in the field of cell biology, such as immunofluorescence staining and immunohistochemistry, assisting in research on protein subcellular localization and cell structure analysis, ensuring the reliability of experimental results.

For research use only. We do not sell to patients.

  • Purity: 99.36%
  • Molecular Weight:145.06 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Experimental Validation Results for Mouse IgG1 kappa, Isotype Control
  • Mouse IgG1 kappa, Isotype Control Chemical Structure
    Mouse IgG1 kappa, Isotype Control Chemical Structure
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
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    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]

    Customer Validation
     Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). Quantification and qualification of urine protein.

  • 1/16

    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]

    Customer Validation
     Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). The levels of anti-double-stranded DNA antibodies and antinuclear antibodies in the peripheral blood of the mice on day 17.

  • 1/16

    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Aug 15. [Abstract]

    Customer Validation
     Effect of cytokine signaling blockade on ALL cell survival in co-culture with stromal populations. ALL cells were co-cultured with early mesenchymal progenitors, adipogenic progenitors, or cultured alone. Cell survival was assessed after treatment with blocking antibodies against IL7, Osteopontin, or the CXCR4 inhibitor Plerixafor (1 nM; 7 days), Mouse IgG1 kappa, Isotype Control (1 ug/mL; 7 days).

  • 1/16

    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Aug 15. [Abstract]

    Customer Validation
     Effect of cytokine signaling blockade on ALL cell survival in co-culture with stromal populations. ALL cells were co-cultured with early mesenchymal progenitors, adipogenic progenitors, or cultured alone. Effect of VCAM1 blockade on ALL cell viability in co-culture or monoculture. Effect of blocking integrin beta 1 (ITGB1) using a blocking antibody or the small peptidomimetic drug BIO-1211 (50 uM; 7 days), Mouse IgG1 kappa, Isotype Control (1 ug/mL; 7 days)on ALL cell viability in co-culture or monoculture.

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    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Jul 23:S1074-7613(24)00351-0. [Abstract]

    Customer Validation
     HUVECs were pretreated with IgG (Mouse IgG1 kappa, Isotype Control) or anti-Notch1 antibodies at 10 μg/mL for 2 h, then given control exosomes or stroke exosomes (15 μg/mL) for 24 h. mRNA expression of Notch1, VCAM1, P16, and P53 were assessed by quantitative real-time PCR. n = 6 per group.

  • 1/16

    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Jul 23:S1074-7613(24)00351-0. [Abstract]

    Customer Validation
     HUVECs were pretreated with IgG (Mouse IgG1 kappa, Isotype Control) or anti-Notch1 antibodies at 10 μg/mL for 2 h, then given control exosomes or stroke exosomes (15 μg/mL) for 24 h. Flow cytometry analysis of Notch1, VCAM1, P16, and P53 expression in HUVECs.

  • 1/16

    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Jul 23:S1074-7613(24)00351-0. [Abstract]

    Customer Validation
     HUVECs were pretreated with IgG (Mouse IgG1 kappa, Isotype Control) or anti-Notch1 mAb at 10 μg/mL for 2 h, then given control exosomes or stroke exosomes (15 μg/mL) for 24 h. THP-1 cells were labeled with fluorescence dye, then cell adhesion assay was performed. Representative images of adhesive cells.

  • 1/16

    Mouse IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Jul 23:S1074-7613(24)00351-0. [Abstract]

    Customer Validation
     Wild-type mice received intraperitoneal (i.p.) injections of IgG control (Mouse IgG1 kappa, Isotype Control ) or anti-VCAM1 mAb (5 mg/kg/week) following MCAO surgery. Flow cytometry analysis was conducted at day 14 after surgery. Counts of Ly6Chigh monocytes (left) and neutrophils (right) in aorta. n = 6 mice per group. Data were representative of three independent experiments.

  • Mouse IgG1 kappa, Isotype Control Chemical Structure
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  • Mouse IgG1 kappa, Isotype Control
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