Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

Cat. No.: HY-P99137 Purity: 99.39%: Data Sheet
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Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3).

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Based on 5 publication(s) in Google Scholar

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Featured Recommendations:

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5 Publications Citing Use of MCE Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

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Histological Imaging/Staining

In Vivo Imaging

: Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]; Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). Quantification and qualification of urine protein.

: Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]; Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). The levels of anti-double-stranded DNA antibodies and antinuclear antibodies in the peripheral blood of the mice on day 17.

: Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]; The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative image of heart and wheat germ agglutinin (WGA) staining and quantification of WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.

: Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]; The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative hematoxylin and eosin (H&E) staining and Masson’s trichrome staining showing heart size, cardiomyocyte size, and fibrosis in WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.

: Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]; The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Quantification left ventricular end-diastolic anterior wall thickness (LVAW;d), left ventricular end-diastolic posterior wall thickness (LVPW;d), Ejection fraction (EF), Fractional shortening (FS) or left ventricular (LV) mass.

: Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]; The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative M-mode echocardiograms of the left ventricle in WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.

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Description	Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3)^[1]^[2].
Isotype	Mouse IgG1 kappa
Recommend Isotype Controls	Mouse IgG1 kappa, Isotype Control
Species Reactivity	Mouse
IC₅₀ & Target	IFNAR1
In Vitro	Anti-Mouse IFNAR1 Antibody (MAR1-5A3) (20 μg/ml, 18 h) inhibits IFNAR1 signaling in Bone marrow-derived macrophages^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Related Antibodies
In Vivo	Anti-Mouse IFNAR1 Antibody (MAR1-5A3) (250-500 μg/mouse for i.p.) inhibits IFNAR1 signaling in WT mice model^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID	15975 [NCBI]
Accession	P33896
Application	in vivo IFNAR-1 blockade; in vitro IFNAR-1 blockade; Western blot; Flow Cytometry; ELISA
Conjugated	Unconjugated
Reconsititution	The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight	150 kDa
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Anti-Mouse IFNAR1 Antibody (MAR1-5A3)]
Formulation	Please refer to the lot-specific COA for specific buffer information.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity	Immobilized IFNAR1 Protein, Mouse (HEK293, His, HY-P73127) can bind Anti-Mouse IFNAR1 Antibody (MAR1-5A3). The EC₅₀ for this effect is 12.87 ng/mL.
Purity & Documentation	Purity: 99.39% Select Batch: Data Sheet (260 KB) SDS (251 KB) COA (232 KB) SDS-PAGE (70 KB) SEC-HPLC (255 KB) Inhibitory Antibodies User Guide (603 KB)
References	[1]. Macal M, et al. Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection. Immunity. 2018 Apr 17;48(4):730-744.e5. [Content Brief] [2]. Schliehe C, et al. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol. 2015 Jan;16(1):67-74. [Content Brief]

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Related Classifications

Inflammation/Immunology

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IFNAR1 Antibody (MAR1-5A3)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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Immobilized IFNAR1 Protein, Mouse (HEK293, His, HY-P73127) can bind Anti-Mouse IFNAR1 Antibody (MAR1-5A3). The EC₅₀ for this effect is 12.87 ng/mL.
1/16

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]

Customer Validation
Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). Quantification and qualification of urine protein.
1/16

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]

Customer Validation
Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). The levels of anti-double-stranded DNA antibodies and antinuclear antibodies in the peripheral blood of the mice on day 17.
1/16

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

Customer Validation
The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative image of heart and wheat germ agglutinin (WGA) staining and quantification of WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.
1/16

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

Customer Validation
The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative hematoxylin and eosin (H&E) staining and Masson’s trichrome staining showing heart size, cardiomyocyte size, and fibrosis in WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.
1/16

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

Customer Validation
The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Quantification left ventricular end-diastolic anterior wall thickness (LVAW;d), left ventricular end-diastolic posterior wall thickness (LVPW;d), Ejection fraction (EF), Fractional shortening (FS) or left ventricular (LV) mass.
1/16

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

Customer Validation
The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative M-mode echocardiograms of the left ventricle in WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.
1/16

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