2. Immunology/Inflammation
  3. IFNAR
  4. IFN alpha-IFNAR-IN-1 hydrochloride

IFN alpha-IFNAR-IN-1 hydrochloride 

Cat. No.: HY-12836A Purity: 99.87%
COA Handling Instructions

IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM).

For research use only. We do not sell to patients.

IFN alpha-IFNAR-IN-1 hydrochloride Chemical Structure

IFN alpha-IFNAR-IN-1 hydrochloride Chemical Structure

CAS No. : 2070014-98-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 131 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 131 In-stock
Solid
5 mg USD 119 In-stock
10 mg USD 158 In-stock
50 mg USD 422 In-stock
100 mg USD 739 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 18 publication(s) in Google Scholar

Other Forms of IFN alpha-IFNAR-IN-1 hydrochloride:

Top Publications Citing Use of Products

    IFN alpha-IFNAR-IN-1 hydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2016 Jul 14;6:29665.  [Abstract]

    PAMs are first pretreated with IFN-alpha-IFNAR-IN-1 or mock pretreated with medium containing DMSO for 2 h. The cells are then infected with the HP-PRRSV virus at an MOI of 5 or mock-infected with DMEM for 12 h and 16 h, respectively. The cell lysates are collected and analyzed by western blot. The fold change of SAMHD1 protein is expressed as densitometric units of the band normalized to the β-actin level relative to the uninfected control. The error bar represents standard deviation from three

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    Description

    IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM)[1].

    In Vitro

    IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) specifically inhibits MVA-induced IFN-a responses by BMpDCs[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    315.86

    Appearance

    Solid

    Formula

    C18H18ClNS
    CAS No.
    SMILES

    CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (316.60 mM; Need ultrasonic)

    H2O : 16.67 mg/mL (52.78 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1660 mL 15.8298 mL 31.6596 mL
    5 mM 0.6332 mL 3.1660 mL 6.3319 mL
    10 mM 0.3166 mL 1.5830 mL 3.1660 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.87%

    COA (253 KB) HNMR (292 KB) LCMS (256 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    IFN alpha-IFNAR-IN-12070014-98-9IFNARInterferon-α/β receptorInterferon-alpha/beta receptormurine bone-marrow-derivedBM-pDCsFlt3-L-differentiated pDC culturesInhibitorinhibitorinhibit

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