1. Immunology/Inflammation
  2. Cyclic GMP-AMP Synthase
  3. RU.521

RU.521 (Synonyms: RU320521)

Cat. No.: HY-114180 Purity: 99.89%
Handling Instructions

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).

For research use only. We do not sell to patients.

RU.521 Chemical Structure

RU.521 Chemical Structure

CAS No. : 2262452-06-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 132 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
50 mg USD 820 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1].

IC50 & Target

IC50: 0.7 μM (dsDNA)[1]

In Vitro

RU.521 (0.1 nM-1000 μM; 72 h) suppresses dsDNA-induced signaling in macrophage cells[1].
RU.521(0-100 μM; 24 h) selectively inhibits cGAS-mediated signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RU.521 (5 mg/kg ; i.p. once) reduces symptoms from sepsis in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 8-week-old male mice with LPS injection[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg once
Result: Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.
Molecular Weight

415.23

Formula

C19H12Cl2N4O3

CAS No.
SMILES

O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (200.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4083 mL 12.0415 mL 24.0830 mL
5 mM 0.4817 mL 2.4083 mL 4.8166 mL
10 mM 0.2408 mL 1.2042 mL 2.4083 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.89%

References
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Product Name:
RU.521
Cat. No.:
HY-114180
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