1. Immunology/Inflammation
  2. IFNAR
  3. IFN alpha-IFNAR-IN-1

IFN alpha-IFNAR-IN-1 

Cat. No.: HY-12836
Handling Instructions

IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).

For research use only. We do not sell to patients.

IFN alpha-IFNAR-IN-1 Chemical Structure

IFN alpha-IFNAR-IN-1 Chemical Structure

CAS No. : 844882-93-5

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Top Publications Citing Use of Products

    IFN alpha-IFNAR-IN-1 purchased from MCE. Usage Cited in: Sci Rep. 2016 Jul 14;6:29665.

    PAMs are first pretreated with IFN-alpha-IFNAR-IN-1 or mock pretreated with medium containing DMSO for 2 h. The cells are then infected with the HP-PRRSV virus at an MOI of 5 or mock-infected with DMEM for 12 h and 16 h, respectively. The cell lysates are collected and analyzed by western blot. The fold change of SAMHD1 protein is expressed as densitometric units of the band normalized to the β-actin level relative to the uninfected control. The error bar represents standard deviation from three
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    Description

    IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). IC50 value: Target: IFN alpha-IFNAR interaction inhibitor IFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].

    Molecular Weight

    279.40

    Formula

    C₁₈H₁₇NS

    CAS No.
    SMILES

    CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Keywords:

    IFN alpha-IFNAR-IN-1IFNARInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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    Product Name:
    IFN alpha-IFNAR-IN-1
    Cat. No.:
    HY-12836
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