1. Immunology/Inflammation
    JAK/STAT Signaling
    Epigenetics
    Stem Cell/Wnt
    Anti-infection
  2. IFNAR
    JAK
    STAT
    HCV
  3. RO8191

RO8191 (Synonyms: RO4948191)

Cat. No.: HY-W063968
Handling Instructions

RO8191 (RO4948191), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon.

For research use only. We do not sell to patients.

RO8191 Chemical Structure

RO8191 Chemical Structure

CAS No. : 691868-88-9

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Description

RO8191 (RO4948191), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon[1].

IC50 & Target[1]

JAK1

 

IFNAR2

 

In Vitro

RO8191 (RO4948191) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice[1].
RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells[1].
RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B[1].

In Vivo

RO8191 (RO4948191; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice[1].

Molecular Weight

373.21

Formula

C₁₄H₅F₆N₅O

CAS No.

691868-88-9

SMILES

FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RO8191RO4948191RO 8191RO-8191RO 4948191RO-4948191IFNARJAKSTATHCVInterferon-α/β receptorInterferon-alpha/beta receptor Janus kinaseHepatitis C virusimidazonaphthyridineorallyinterferonISGsEMCVrepliconIFNAR2JAK1IFNAR1Tyk2Inhibitorinhibitorinhibit

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RO8191
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HY-W063968
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