1. Immunology/Inflammation
    JAK/STAT Signaling
    Epigenetics
    Stem Cell/Wnt
    Anti-infection
  2. IFNAR
    JAK
    STAT
    HCV
    HBV
  3. RO8191

RO8191 (Synonyms: CDM-3008; RO4948191)

Cat. No.: HY-W063968 Purity: >99.0%
Handling Instructions

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity.

For research use only. We do not sell to patients.

RO8191 Chemical Structure

RO8191 Chemical Structure

CAS No. : 691868-88-9

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5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon[1]. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity[2].

IC50 & Target[1]

JAK1

 

IFNAR2

 

In Vitro

RO8191 (CDM-3008) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice[1].
RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells[1].
RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RO8191 (CDM-3008; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

373.21

Formula

C₁₄H₅F₆N₅O

CAS No.

691868-88-9

SMILES

FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >99.0%

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Keywords:

RO8191CDM-3008RO4948191RO 8191RO-8191CDM3008CDM 3008RO 4948191RO-4948191IFNARJAKSTATHCVHBVInterferon-α/β receptorInterferon-alpha/beta receptor Janus kinaseHepatitis C virusHepatitis B virusimidazonaphthyridineorallyinterferonISGsEMCVrepliconIFNAR2JAK1IFNAR1Tyk2cccDNAInhibitorinhibitorinhibit

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RO8191
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