1. Immunology/Inflammation
  2. STING

C-176 (Synonyms: STING inhibitor 1)

Cat. No.: HY-112906 Purity: >98.0%
Handling Instructions

C-176 is a strong and covalent mouse STING inhibitor.

For research use only. We do not sell to patients.

C-176 Chemical Structure

C-176 Chemical Structure

CAS No. : 314054-00-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

C-176 is a strong and covalent mouse STING inhibitor.

IC50 & Target

STING[1].

In Vitro

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1].

In Vivo

Notably, treatment of Trex1−/− mice with C-176 resulted in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart. Wild-type mice on a two-week treatment with C-176 show no evident signs of overt toxicity. We next conducted a three-month trial with C-176 in Trex1−/− mice, which demonstrated marked amelioration of various signs of systemic inflammation[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 155 mg/mL (432.85 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7926 mL 13.9630 mL 27.9259 mL
5 mM 0.5585 mL 2.7926 mL 5.5852 mL
10 mM 0.2793 mL 1.3963 mL 2.7926 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
C57BL/6J mice are used in the study. For the pharmacokinetic studies, wild-type mice are injected intraperitoneally with 750 nM C-176 per mouse in 200 μL corn oil. To assess the in vivo inhibitory effect of C-176, wild-type mice (8-12 weeks of age) are injected either with vehicle or C-176. To assess the in vivo inhibitory effect of H-151, wild-type mice are injected intraperitoneally with 750 nM H-151 per mouse in 200 μl 10% Tween-80 in PBS. After 1 h CMA (112 mg/kg) is administered, and after 4 h mice are euthanized and the serum is collected. The efficacy study in Trex1−/− mice is conducted as follows: mice (2-5 weeks of age) are injected with 7.5 μL of C-176 or DMSO dissolved in 85 μl corn oil twice per day for 11 consecutive days. Mice are euthanized by anaesthetization in a CO2 chamber followed by cervical dislocation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

358.09

Formula

C₁₁H₇IN₂O₄

CAS No.

314054-00-7

SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(I)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
C-176
Cat. No.:
HY-112906
Quantity:

C-176

Cat. No.: HY-112906