1. Immunology/Inflammation
  2. STING
  3. C-176

C-176 

Cat. No.: HY-112906 Purity: 99.22%
Handling Instructions

C-176 is a strong and covalent mouse STING inhibitor.

For research use only. We do not sell to patients.

C-176 Chemical Structure

C-176 Chemical Structure

CAS No. : 314054-00-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    C-176 purchased from MCE. Usage Cited in: J Neuroinflammation. 2020 May 25;17(1):165.

    Western blotting indicated that the level of TBK1 phosphorylation is significantly increased after SAH. Compared with SAH + vehicle group, the phosphorylation of TBK1 is remarkably inhibited by C-176.

    C-176 purchased from MCE. Usage Cited in: Aging Cell. 2020 Jul 14;e13186.

    The BMDMs from the young and aged mice are pretreated with C-176 (20 µM) or STING siRNA followed by stimulation with mtDNA (100 ng/ml). The C-176 treatment effectively inhibits STING activation in both young and aged BMDMs post-mtDNA stimulation, as shown by the decreased protein levels of P-STING and P-TBK1.

    C-176 purchased from MCE. Usage Cited in: Aging Cell. 2020 Jul 14;e13186.

    The BMDMs from the young and aged mice are pretreated with C-176 (20 µM) or STING siRNA followed by stimulation with mtDNA (100 ng/ml). STING inhibition by C-176 blocks the over-activation of NLRP3 signaling in the BMDMs from the young and aged mice post-mtDNA stimulation, as shown by decreased levels of NLRP3 and Cleaved caspase-1 expression.
    • Biological Activity

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    • Customer Review

    Description

    C-176 is a strong and covalent mouse STING inhibitor[1].

    IC50 & Target

    STING[1].

    In Vitro

    C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity[1].
    C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1−/− mice[1].
    C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1−/− mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: WT type mice.
    Dosage: 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
    Administration: Intraperitoneally, once.
    Result: Significantly reduced Serum levels of type I IFNs and IL-6.
    Molecular Weight

    358.09

    Formula

    C₁₁H₇IN₂O₄

    CAS No.

    314054-00-7

    SMILES

    O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(I)C=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (349.07 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7926 mL 13.9630 mL 27.9259 mL
    5 mM 0.5585 mL 2.7926 mL 5.5852 mL
    10 mM 0.2793 mL 1.3963 mL 2.7926 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.98 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.98 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.98 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.22%

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    Keywords:

    C-176C176C 176STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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    Product Name:
    C-176
    Cat. No.:
    HY-112906
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