314054-00-7
314054-00-7
Chemical Structure
C-176
- CAS 番号: 314054-00-7
- Formula:C11H7IN2O4
- Molecular Weight:358.09
IUPAC Name: N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
InChIKey: JBIKQXOZLBLMKI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(I)C=C2
Biological Activity: C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2].
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C-176 | 98.47% | C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING. | ||||||||||||||||||||
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References
- [1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. [Content Brief]
- [2]. Zhang LM, et al. STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury. J Neurochem. 2022 Sep;162(5):444-462. [Content Brief]
Keywords
