STING ligand-3
Based on 1 Customer Validation
STING ligand-3 is a Ligand for Target Protein for PROTAC activity control. STING ligand-3 can be used to synthesize Anti-inflammatory agent 70 (HY-157570).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.21%
- CAS. Nr.: 2762552-73-6
- Formel: C15H11N3O7
- Molecular Weight:345.26
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 2762552-73-6
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Appearance Solid
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Molecular Weight 345.26
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Formel C15H11N3O7
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Color Light yellow to yellow
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SMILES
OC(/C=C/C(NC(C=C1)=CC=C1NC(C2=CC=C([N+]([O-])=O)O2)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (289.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Reinheit & Dokumentation
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Data Sheet (241 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8964 mL | 14.4818 mL | 28.9637 mL | 72.4092 mL |
| 5 mM | 0.5793 mL | 2.8964 mL | 5.7927 mL | 14.4818 mL | |
| 10 mM | 0.2896 mL | 1.4482 mL | 2.8964 mL | 7.2409 mL | |
| 15 mM | 0.1931 mL | 0.9655 mL | 1.9309 mL | 4.8273 mL | |
| 20 mM | 0.1448 mL | 0.7241 mL | 1.4482 mL | 3.6205 mL | |
| 25 mM | 0.1159 mL | 0.5793 mL | 1.1585 mL | 2.8964 mL | |
| 30 mM | 0.0965 mL | 0.4827 mL | 0.9655 mL | 2.4136 mL | |
| 40 mM | 0.0724 mL | 0.3620 mL | 0.7241 mL | 1.8102 mL | |
| 50 mM | 0.0579 mL | 0.2896 mL | 0.5793 mL | 1.4482 mL | |
| 60 mM | 0.0483 mL | 0.2414 mL | 0.4827 mL | 1.2068 mL | |
| 80 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9051 mL | |
| 100 mM | 0.0290 mL | 0.1448 mL | 0.2896 mL | 0.7241 mL |
STING ligand-3 Related Classifications
HY-47709 Related Classifications
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