1. Immunology/Inflammation
  2. STING
  3. C-178

C-178 

Cat. No.: HY-123963
Handling Instructions

C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human.C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING).

For research use only. We do not sell to patients.

C-178 Chemical Structure

C-178 Chemical Structure

CAS No. : 329198-87-0

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Description

C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human.C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1].

IC50 & Target

IC50: STING[1]

Molecular Weight

322.27

Formula

C₁₇H₁₀N₂O₅

CAS No.

329198-87-0

SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2

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Room temperature in continental US; may vary elsewhere

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
C-178
Cat. No.:
HY-123963
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