C-178
Based on 7 publication(s) in Google Scholar
C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 329198-87-0
- Formula: C17H10N2O5
- Molecular Weight:322.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) C-178
More- Nat Commun. 2023 May 23;14(1):2950. [Abstract]
- Cell Death Differ. 2025 Jun;32(6):1167-1179. [Abstract]
- Pharmacol Res. 2023 Oct:196:106939. [Abstract]
- Leukemia. 2023 Dec;37(12):2457-2467. [Abstract]
- Mol Ther Methods Clin Dev. 2025 Jul 28;33(3):101542. [Abstract]
- Dev Comp Immunol. 2023 Feb:139:104567. [Abstract]
- Patent. US20250018019A1.
Customer Validation & Images
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Flow Cytometry
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WB
Biological Activity
STING[1]
C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells[1].C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1[1].C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages[1].C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse bone marrow-derived macrophages (BMDMs)
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Concentration:0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
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Incubation Time:1 hour
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Result:Inhibited CMA-induced p-TBK1 expression as a does dependent manner.
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Cell Line:Mouse bone marrow-derived macrophages (BMDMs)
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Concentration:1 μM
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Incubation Time:1 hour
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Result:Downregulated Ifnb1 expression in BMDMs.
Chemical Information
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CAS No. 329198-87-0
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Appearance Solid
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Molecular Weight 322.27
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Formula C17H10N2O5
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Color Yellow to orange
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SMILES
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (7)
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Journal Impact Factor
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Most Recent
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Nat Commun
Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation. [Abstract]2023 May 23;14(1):2950. PMID: 37221157 -
Cell Death Differ
STING directly interacts with PAR to promote apoptosis upon acute ionizing radiation-mediated DNA damage. [Abstract]2025 Jun;32(6):1167-1179. PMID: 39939798 -
Pharmacol Res
A sequential scheme including PTT and 2'3'-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway. [Abstract]2023 Oct:196:106939. PMID: 37758101
C-178 purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2023 Oct:196:106939. [Abstract]
Phosphorylation levels of TBK1 in RAW264.7 cells at 3, 6, and 9 hours after PTT treatment, with or without 1-hour pre-treatment with the STING inhibitor C178 (0.5 μM).
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Leukemia
STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation. [Abstract]2023 Dec;37(12):2457-2467. PMID: 37816954 -
Mol Ther Methods Clin Dev
Enhanced B cell electroporation efficiency via inhibition of DNA-induced apoptosis and pyroptosis with pan-caspase inhibitor. [Abstract]2025 Jul 28;33(3):101542. PMID: 40821855
C-178 purchased from MedChemExpress. Usage Cited in: Mol Ther Methods Clin Dev. 2025 Jul 28;33(3):101542. [Abstract]
B cells were treated with the indicated small molecule inhibitor, and Annexin V/PI staining was performed 24 h post-electroporation via flow cytometry. C-178: STING inhibitor (3.5 μM), MRT67307: TBK1 inhibitor (0.2 μM).
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Dev Comp Immunol
Bovine cyclic GMP-AMP synthase recognizes exogenous double-stranded DNA and activates the STING-depended interferon β production pathway. [Abstract]2023 Feb:139:104567. PMID: 36228808 -
Solvent & Solubility
DMSO : 41.67 mg/mL (129.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1030 mL | 15.5149 mL | 31.0299 mL | 77.5747 mL |
| 5 mM | 0.6206 mL | 3.1030 mL | 6.2060 mL | 15.5149 mL | |
| 10 mM | 0.3103 mL | 1.5515 mL | 3.1030 mL | 7.7575 mL | |
| 15 mM | 0.2069 mL | 1.0343 mL | 2.0687 mL | 5.1716 mL | |
| 20 mM | 0.1551 mL | 0.7757 mL | 1.5515 mL | 3.8787 mL | |
| 25 mM | 0.1241 mL | 0.6206 mL | 1.2412 mL | 3.1030 mL | |
| 30 mM | 0.1034 mL | 0.5172 mL | 1.0343 mL | 2.5858 mL | |
| 40 mM | 0.0776 mL | 0.3879 mL | 0.7757 mL | 1.9394 mL | |
| 50 mM | 0.0621 mL | 0.3103 mL | 0.6206 mL | 1.5515 mL | |
| 60 mM | 0.0517 mL | 0.2586 mL | 0.5172 mL | 1.2929 mL | |
| 80 mM | 0.0388 mL | 0.1939 mL | 0.3879 mL | 0.9697 mL | |
| 100 mM | 0.0310 mL | 0.1551 mL | 0.3103 mL | 0.7757 mL |
C-178 Related Classifications
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