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Ifnar1 - interferon (alpha and beta) receptor 1 Gene

Also Known as Ifar; Ifrc; Ifnar; Infar

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15975

About Ifnar1

Chromosome 16: 91,282,126-91,304,329 forward strand.GRCm39:CM001009.3

This gene has 8 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 69 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 8.7), CNS E18 (RPKM 8.4) and 28 other tissues.

Summary

Enables type I interferon binding activity and type I interferon receptor activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and response to lipopolysaccharide. Acts upstream of or within several processes, including defense response to virus; positive regulation of cytokine production; and regulation of peptidyl-tyrosine phosphorylation. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnar1 Products (1)

mRNA	Protein	Name
NM_010508.2	NP_034638.2	interferon alpha/beta receptor 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interferon receptor activity	IMP IMP: Inferred from mutant phenotype	16139798	MGI
enables type I interferon binding	IPI IPI: Inferred from physical interaction	23872679	MGI
enables type I interferon receptor activity	IDA IDA: Inferred from direct assay	23872679	MGI
enables type I interferon receptor activity	IMP IMP: Inferred from mutant phenotype	14532120	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell activation	IGI IGI: Inferred from genetic interaction	17164250	MGI
involved in cellular response to interferon-alpha	IMP IMP: Inferred from mutant phenotype	14532120	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	17277142	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	27129230	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	31623059	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24598055	MGI
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	24598055	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	23997220	MGI
acts upstream of or within positive regulation of type II interferon production	IGI IGI: Inferred from genetic interaction	17164250	MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	21606371	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	23872679	MGI
acts upstream of or within type I interferon production	IMP IMP: Inferred from mutant phenotype	15800576	MGI
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	23872679	MGI
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	14532120	MGI
acts upstream of type II interferon production	IGI IGI: Inferred from genetic interaction	17164250	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14532120	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ifnar1 Protein Structure

FN3

Interfer-bind

FN3

0
100
200
300
400
500
590 a.a.

Protein Preferred Names	Protein Names
interferon alpha/beta receptor 1	IFN-R-1 IFN-alpha/beta receptor 1 IFN-alpha/betaR INF-a receptor type I interferon receptor 1

Recombinant Ifnar1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73127	IFNAR1 Protein, Mouse (HEK293, His)	P33896/NP_034638.2(E27-T429)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78308	IFNAR1 Protein, Mouse (HEK293, Fc)	P33896 (E27-T429)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78309	IFNAR1 Protein, Mouse (HEK293, His-Avi)	P33896 (E27-T429)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137978A	Ezurpimtrostat hydrochloride	Inhibitor	99.26%	Phase 2
HY-137978	Ezurpimtrostat	Inhibitor	99.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17663	KMR-206	Activator	98.86%	Unkown
HY-P1758A	IFN-α Receptor Recognition Peptide 1 acetate	Modulator	99.29%	Unkown
HY-P1758	IFN-α Receptor Recognition Peptide 1	Modulator	/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991251	QX006N	Inhibitor	99.9%	Unkown
HY-P992182	ANB032	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ifnar1	NCBI	NCBI:3454
Macaca fascicularis	Ifnar1	NCBI	NCBI:101926190
Macaca mulatta	Ifnar1	NCBI	NCBI:699604