2. Gene
  3. Ifnar1 - interferon (alpha and beta) receptor 1 Gene

Ifnar1 - interferon (alpha and beta) receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ifar; Ifrc; Ifnar; Infar

Gene ID: 15975 | Gene type: protein coding

About Ifnar1

Chromosome 16: 91,282,126-91,304,329 forward strand.GRCm39:CM001009.3

This gene has 8 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 69 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 8.7), CNS E18 (RPKM 8.4) and 28 other tissues.

Summary

Enables type I interferon binding activity and type I interferon receptor activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and response to lipopolysaccharide. Acts upstream of or within several processes, including defense response to virus; positive regulation of cytokine production; and regulation of peptidyl-tyrosine phosphorylation. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnar1 Products(1)

mRNA Protein Name
NM_010508.2 NP_034638.2 interferon alpha/beta receptor 1 precursor

Ifnar1 Protein Structure

FN3

FN3: cl21522 (18 - 113)

Interfer-bind

Interfer-bind: pfam09294 (125 - 223)

FN3

FN3: cl21522 (220 - 318)

FN3

FN3: cl21522 (334 - 421)

  • 0
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  • 500
  • 590 a.a.
Protein Preferred Names Protein Names

interferon alpha/beta receptor 1

IFN-R-1

IFN-alpha/beta receptor 1

IFN-alpha/betaR

INF-a receptor

type I interferon receptor 1

Recombinant Ifnar1 Proteins

Cat. No. Product Name Accession Purity
HY-P73127 IFNAR1 Protein, Mouse (HEK293, His) P33896/NP_034638.2(E27-T429) ≥95%
HY-P78308 IFNAR1 Protein, Mouse (HEK293, Fc) P33896 (E27-T429) ≥95%
HY-P78309 IFNAR1 Protein, Mouse (HEK293, His-Avi) P33896 (E27-T429) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W063968 RO8191 ≥99.0% Unkown
HY-RS06579 IFNAR1 Human Pre-designed siRNA Set A / Unkown
HY-RS06580 Ifnar1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06581 Ifnar1 Rat Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99137 Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ifnar1 NCBI NCBI:3454
Macaca fascicularis Ifnar1 NCBI NCBI:101926190
Macaca mulatta Ifnar1 NCBI NCBI:699604