IFNAR1 - interferon alpha and beta receptor subunit 1 Gene

Also Known as AVP; IFRC; IFNAR; IFNBR; IMD106; IFN-alpha-REC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3454

About IFNAR1

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,324,395-33,359,864 (from NCBI)

This gene has 29 transcripts (splice variants), 226 orthologues and 11 paralogues. Ubiquitous expression in thyroid (RPKM 14.1), urinary bladder (RPKM 11.9) and 25 other tissues.

Summary

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an Antiviral factor. [provided by RefSeq, Jul 2020]

IFNAR1 Products (8)

mRNA	Protein	Name
NM_001384499.1	NP_001371428.1	interferon alpha/beta receptor 1 isoform 3 precursor
NM_001384502.1	NP_001371431.1	interferon alpha/beta receptor 1 isoform 6
NM_000629.3	NP_000620.2	interferon alpha/beta receptor 1 isoform 2 precursor
NM_001384504.1	NP_001371433.1	interferon alpha/beta receptor 1 isoform 8
NM_001384500.1	NP_001371429.1	interferon alpha/beta receptor 1 isoform 4
NM_001384501.1	NP_001371430.1	interferon alpha/beta receptor 1 isoform 5 precursor
NM_001384503.1	NP_001371432.1	interferon alpha/beta receptor 1 isoform 7 precursor
NM_001384498.1	NP_001371427.1	interferon alpha/beta receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables JAK pathway signal transduction adaptor activity	IDA IDA: Inferred from direct assay	8605876	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	7813427	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7665574	GOA
enables type I interferon receptor activity	IDA IDA: Inferred from direct assay	7665574	GOA
enables type I interferon receptor activity	IMP IMP: Inferred from mutant phenotype	31270247	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	7526154	GOA
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	7813427	GOA
involved in positive regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	25930096	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	7665574	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14532120	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	35442418	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNAR1 Protein Structure

Tissue_fac

Interfer-bind

0
100
200
300
400
500
557 a.a.

Protein Preferred Names	Protein Names
interferon alpha/beta receptor 1	CRF2-1 IFN-R-1 IFN-alpha/beta receptor 1 IFNalpha/beta receptor 1 alpha-type antiviral protein beta-type antiviral protein cytokine receptor class-II member 1 cytokine receptor family 2 member 1 interferon (alpha, beta and omega) receptor 1 interferon receptor 1 interferon-alpha/beta receptor alpha chain interferon-beta receptor 1 type I interferon receptor 1

IFNAR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFNAR1	P17181	STAT1	Homo sapiens	P42224	Pull Down	9121453
Intra	IFNAR1	P17181	STAT2	Homo sapiens	P52630	Pull Down	9121453
Intra	IFNAR1	P17181	STAT2	Homo sapiens	P52630	Pull Down	12220192
Intra	IFNAR1	P17181	LAPTM4B	Homo sapiens	Q86VI4	Y2H Prey Pooling	32296183
Intra	IFNAR1	P17181	LAPTM4B	Homo sapiens	Q86VI4	Validated Y2H	32296183
Intra	IFNAR1	P17181	LAPTM4B	Homo sapiens	Q86VI4	Y2H Array	32296183
Intra	IFNAR1	P17181	FBXW11	Homo sapiens	Q9UKB1	Anti Tag CoIP	33961781
Intra	IFNAR1	P17181	FBXW11	Homo sapiens	Q9UKB1	Anti Bait CoIP	14532120
Intra	IFNAR1	P17181	FBXW11	Homo sapiens	Q9UKB1	Anti Tag CoIP	14532120
Intra	IFNAR1	P17181	FBXW11	Homo sapiens	Q9UKB1	Pull Down	14532120

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNAR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70483	IFNAR1 Protein, Human (HEK293, His)	P17181-1 (K28-K436)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74859	IFNAR1 Protein, Human (HEK293, Fc)	P17181-1 (K28-K436)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P78141	IFNAR1 Protein, Human (Biotinylated, HEK293, His-Avi)	P17181-1 (K28-K436)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78457	IFNAR1 Protein, Human (HEK293, His-Avi)	P17181-1 (K28-K436)	≥ 95%, as determined by Bis-Tris PAGE.

IFNAR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83367	Interferon alpha/beta Receptor 1 Antibody (YA3112)	WB, IP	Human
HY-P83367A	Interferon alpha/beta Receptor 1 Antibody (YA3112)(PBS only)	WB, IP	Human
HY-P84136	Interferon alpha/beta receptor 1 Antibody (YA3833)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84136A	Interferon alpha/beta receptor 1 Antibody (YA3833)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ehf Ebola Fever Ebola Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Yellow Fever	Urban Yellow Fever Jungle Yellow Fever Sylvatic Yellow Fever Yf Yellow Fever, Sylvan Bronze John Yellow Jack Yf- [Yellow Fever] Febris Flava
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Listeriosis	Listeria Infection Infection By Listeria Monocytogenes Listeria Monocytogenes Infection Listeria Infections Listerial Foodborne Infection Circling Disease Infection Due To Listeria Monocytogenes Listerellosis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Dengue Hemorrhagic Fever	Severe Dengue Dengue Haemorrhagic Fever Dhf Severe Dengue Haemorrhagic Fever Severe Dengue Fever Dengue Shock Syndrome
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
X-Linked Immunodeficiency 74	Immunodeficiency 74, Covid-19-Related, X-Linked Imd74 Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection Tlr7 Deficiency X-Linked Immunodeficiency 74,Covid-19-Related
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Dengue Shock Syndrome	Dss
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Immunodeficiency 106 Viral Infections	Immunodeficiency 106, Susceptibility To Viral Infections IMD106 Ifnar1 Deficiency
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Zika Fever	Zika Virus Infection Zika Virus Disease Zika Virus Zika Virus Fever Mosquito-Borne Viral Fever, Zika
Conjunctival Disease	Conjunctival Diseases Conjunctival Disorder
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
West Nile Fever
Immunodeficiency 35	Tyrosine Kinase 2 Deficiency IMD35 Tyk2 Deficiency Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis Susceptibility To Infection Due To Tyk2 Deficiency Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive Hies With Atypical Mycobacteriosis, Autosomal Recessive Autosomal Recessiv Hies With Atypical Mycobacteriosis Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency Autosomal Recessive Hies With Atypical Mycobacteriosis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Septicemic Plague	Plague, Septicemic
Dengue Disease	Dengue Fever Dengue Df Dengue Shock Syndrome Dengue Virus Infection Breakbone Fever Classic Dengue Classical Dengue Dengue Hemorrhagic Fever Hemorrhagic Dengue Philippine Hemorrhagic Fever Singapore Hemorrhagic Fever Thai Hemorrhagic Fever Severe Dengue Dengue Fever Without Warning Signs Dengue Haemorrhagic Fever Grade 1 Dengue Haemorrhagic Fever Without Warning Signs Bangkok Haemorrhagic Fever Singapore Haemorrhagic Fever Thailand Haemorrhagic Fever Southeast Asia Haemorrhagic Fever Dhf -[Dengue Haemorrhagic Fever] Dengue Fever With Warning Signs Dengue Haemorrhagic Fever With Warning Signs Dengue Haemorrhagic Fever Grade 2 Philippine Haemorrhagic Fever
Alkhurma Hemorrhagic Fever	Alkhumra Haemorrhagic Fever
Crimean-Congo Hemorrhagic Fever	Crimean Hemorrhagic Fever Cchf Congo Hemorrhagic Fever Hemorrhagic Fever, Crimean Chf Congo Virus Congo-Crimean Hemorrhagic Fever Congo Fever Hemorrhagic Fever Crimean-Congo Cchf - [Crimean-Congo Haemorrhagic Fever] Kara Mikh Typhoid Fever Xīnjiāng Haemorrhagic Fever
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian
Torch Syndrome
Kyasanur Forest Disease	Kfd Monkey Fever Kfd Virus Kyasanur Hemorrhagic Fever Monkey Disease Monkey Diseases Kfd - [ Kyasanur Forest Disease] Monkey Sickness
Herpangina	Vesicular Pharyngitis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Zika Virus Congenital Syndrome	Zikv Congenital Infection
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Lassa Fever	Lf Lassa Hemorrhagic Fever Lf - [Lassa Fever]
St. Louis Encephalitis	Neuroinvasive St. Louis Encephalitis Virus Infection Saint Louis Encephalitis Encephalitis, St. Louis Neuroinvasive Saint Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Neuroinvasive Disease St. Louis Viral Disease Type C Lethargic Encephalitis Encephalitis Type C
Immunodeficiency 28	IMD28 Ifngr2 Deficiency Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive Immunodeficiency 28, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency Msmd Due To Complete Ifngammar2 Deficiency Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency Immunodeficiency, Type 28, Mycobacteriosis
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis
Immunodeficiency 27a	IMD27A Autosomal Recessive Ifngr1 Deficiency Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive Ifngr1 Deficiency, Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis, Ar Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency Familial Disseminated Atypical Mycobacterial Infection Interferon Gamma, Receptor 1, Deficiency Immunodeficiency, Type 27a, Mycobacteriosis, Ar Mycobacterial Disease, Mendelian Susceptibility To
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Papilloma	Papillomatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137978A	Ezurpimtrostat hydrochloride	Inhibitor	99.26%	Phase 2
HY-137978	Ezurpimtrostat	Inhibitor	99.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17663	KMR-206	Activator	98.86%	Unkown
HY-P1758A	IFN-α Receptor Recognition Peptide 1 acetate	Modulator	99.29%	Unkown
HY-P1758	IFN-α Receptor Recognition Peptide 1	Modulator	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991251	QX006N	Inhibitor	99.9%	Unkown
HY-P992182	ANB032	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IFNAR1	VGNC	VGNC:73566
Rattus norvegicus	IFNAR1	RGD	RGD:1305399
Bos taurus	IFNAR1	VGNC	VGNC:30054
Mus musculus	IFNAR1	MGD	MGI:107658
Felis catus	IFNAR1	VGNC	VGNC:67701
Others	IFNAR1	NCBI