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FBXW11 - F-box and WD repeat domain containing 11 Gene

Also Known as Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23291

About FBXW11

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:171,861,549-172,006,638 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

FBXW11 Products (10)

mRNA	Protein	Name
NM_001378974.1	NP_001365903.1	F-box/WD repeat-containing protein 11 isoform D
NM_001378975.1	NP_001365904.1	F-box/WD repeat-containing protein 11 isoform E
NM_001378976.1	NP_001365905.1	F-box/WD repeat-containing protein 11 isoform F
NM_001378977.1	NP_001365906.1	F-box/WD repeat-containing protein 11 isoform G
NM_001378978.1	NP_001365907.1	F-box/WD repeat-containing protein 11 isoform G
NM_001378979.1	NP_001365908.1	F-box/WD repeat-containing protein 11 isoform H
NM_001378980.1	NP_001365909.1	F-box/WD repeat-containing protein 11 isoform A
NM_012300.3	NP_036432.2	F-box/WD repeat-containing protein 11 isoform C
NM_033644.3	NP_387448.2	F-box/WD repeat-containing protein 11 isoform B
NM_033645.3	NP_387449.2	F-box/WD repeat-containing protein 11 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12482991	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	10321728	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20347421	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10644755	GOA
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10644755	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	20347421	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16885022	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16880511	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXW11 Protein Structure

Beta-TrCP_D

F-box-like

WD40

0
100
200
300
400
500
542 a.a.

Protein Preferred Names	Protein Names
F-box/WD repeat-containing protein 11	F-box and WD repeats protein beta-TrCP2

FBXW11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXW11	Q9UKB1	FOXN2	Homo sapiens	P32314	TAP	25609649
Intra	FBXW11	Q9UKB1	FOXN2	Homo sapiens	P32314	Pull Down	25609649
Intra	FBXW11	Q9UKB1	IFNAR1	Homo sapiens	P17181	Anti Tag CoIP	14532120
Intra	FBXW11	Q9UKB1	IFNAR1	Homo sapiens	P17181	Pull Down	14532120
Intra	FBXW11	Q9UKB1	IFNAR1	Homo sapiens	P17181	Anti Bait CoIP	14532120
Intra	FBXW11	Q9UKB1	NFKBIA	Homo sapiens	P25963	TAP	14743216
Intra	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	19159283
Intra	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	TAP	17510365
Intra	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	15070733
Intra	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	19615732
Intra	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	TAP	25609649
Intra	FBXW11	Q9UKB1	SKP1	Homo sapiens	P63208	TAP	21145461
Intra	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	19615732
Intra	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	18354482
Intra	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	21145461
Intra	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	TAP	21145461
Intra	FBXW11	Q9UKB1	CUL1	Homo sapiens	Q13616	TAP	25609649
Intra	FBXW11	Q9UKB1	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20708156
Intra	FBXW11	Q9UKB1	MDM2	Homo sapiens	Q00987	Pull Down	20708156
Intra	FBXW11	Q9UKB1	CTNNB1	Homo sapiens	P35222	TAP	25609649
Intra	FBXW11	Q9UKB1	CTNNB1	Homo sapiens	P35222	TAP	17510365
Intra	FBXW11	Q9UKB1	AMER1	Homo sapiens	Q5JTC6	Anti Tag CoIP	33961781
Intra	FBXW11	Q9UKB1	AMER1	Homo sapiens	Q5JTC6	TAP	17510365
Intra	FBXW11	Q9UKB1	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	22682247
Intra	FBXW11	Q9UKB1	INAVA	Homo sapiens	Q3KP66	Anti Tag CoIP	29420262
Intra	FBXW11	Q9UKB1	WEE1	Homo sapiens	P30291	PLA	25241761
Intra	FBXW11	Q9UKB1	WEE1	Homo sapiens	P30291	Anti Tag CoIP	15070733
Intra	FBXW11	Q9UKB1	REST	Homo sapiens	Q13127	Anti Tag CoIP	18354482

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodevelopmental, Jaw, Eye, And Digital Syndrome	NEDJED
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Rift Valley Fever	Rfv - [Rift Valley Fever]
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Neuronopathy, Distal Hereditary Motor, Type Iid	HMN2D Hmn Iid Dhmn2d Distal Hereditary Motor Neuronopathy Type 2d Distal Hereditary Motor Neuropathy Type Iid Neuronopathy, Distal Hereditary Motor, Type 2d Neuropathy, Distal Hereditary Motor, Type Iid Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant Distal Spinal Muscular Atrophy With Calf Predominance Neuronopathy, Distal Hereditary Motor, 2d Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant Dhmn Iid Neuropathy, Motor, Distal, Hereditary, Type 2d
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Brachydactyly
Distal Hereditary Motor Neuronopathy Type 2	Distal Hereditary Motor Neuropathy, Type Ii Distal Hereditary Motor Neuropathy Type 2 Distal Hereditary Motor Neuropathy Type Ii Hmn Ii Hmn2 Distal Hereditary Motor Neuronopathy, Type Ii Distal Spinal Muscular Atrophy Type 2 Dhmn2 Dsma2 Neuropathy, Motor, Distal, Hereditary, Type Ii Spinal Muscular Atrophy, Jerash Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04816	FBXW11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21128	Fbxw11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27646	Fbxw11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FBXW11	MGD	MGI:2144023
Bos taurus	FBXW11	VGNC	VGNC:28922
Felis catus	FBXW11	VGNC	VGNC:62200
Canis familiaris	FBXW11	VGNC	VGNC:40792
Rattus norvegicus	FBXW11	RGD	RGD:1309121
Macaca mulatta	FBXW11	VGNC	VGNC:72500
Others	FBXW11	NCBI