WEE1 - WEE1 G2 checkpoint kinase Gene

Also Known as WEE1A; WEE1hu

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7465

About WEE1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,573,670-9,589,985 (from NCBI)

This gene has 10 transcripts (splice variants), 227 orthologues and 8 paralogues. Ubiquitous expression in gall bladder (RPKM 23.7), esophagus (RPKM 19.4) and 22 other tissues.

Summary

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and Mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

WEE1 Products (3)

mRNA Protein Name
XM_047427539.1 XP_047283495.1 wee1-like protein kinase isoform X1
NM_003390.4 NP_003381.1 wee1-like protein kinase isoform 1
NM_001143976.2 NP_001137448.1 wee1-like protein kinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15070733 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7743995 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
7743995 GOA
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
8348613 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WEE1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (299 - 568)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
Protein Preferred Names Protein Names

wee1-like protein kinase

  • WEE1 homolog

  • WEE1+ homolog

  • protein kinase

  • wee1A kinase

WEE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WEE1 P30291 BTRC Homo sapiens Q9Y297
Anti Tag CoIP
15070733
Intra
WEE1 P30291 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
WEE1 P30291 FBXW11 Homo sapiens Q9UKB1
Anti Tag CoIP
15070733
Intra
WEE1 P30291 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
WEE1 P30291 PLK1 Homo sapiens P53350
Kinase HTRF
15070733
Cross: Cross-species interaction Intra: Intraspecies interaction

WEE1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87147 Wee1 Antibody (YA6840) WB, IHC-P Human, Monkey

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 20

  • Primary Ciliary Dyskinesia 20

  • CILD20

  • Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus

  • Ics20

  • Immotile Cilia Syndrome 20

  • Dyskinesia, Ciliary, Primary, 20
Vulva Cancer

  • Vulvar Carcinoma

  • Malignant Neoplasm Of Vulva

  • Vulva Carcinoma

  • Carcinoma Of Vulva

  • Vulval Cancer

  • Vulvar Cancer

  • Vulvar Neoplasms

  • Ca Vulva

  • Malignant Tumor Of Vulva

  • Malignant Vulvar Tumor

  • Neoplasm Of Vulva

  • Vulval Neoplasm

  • Vulvar Neoplasm

  • Vulvar Tumor

  • Cancer Of Vulva

  • Malignant Tumour Of Vulva
Beckwith-Wiedemann Syndrome

  • Wiedemann-Beckwith Syndrome

  • BWS

  • Exomphalos-Macroglossia-Gigantism Syndrome

  • Emg Syndrome

  • Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

  • Emg Abnormality

  • Wbs

  • Exomphalos Macroglossia Gigantism Syndrome

  • Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

  • Macroglossia Exomphalos Gigantism
Gum Cancer

  • Malignant Neoplasm Of Gum

  • Malignant Tumor Of Gum

  • Malignant Gingival Tumor

  • Malignant Neoplasm Of Other Sites Of Gum

  • Malignant Tumour Of Gingiva
Vulva Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Vulva

  • Vulvar Squamous Cell Carcinoma

  • Vulvar Epidermoid Carcinoma

  • Squamous Cell Carcinoma Of The Vulva
Breast Cancer

  • Breast Carcinoma

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Male Breast Cancer

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Desmoplastic/Nodular Medulloblastoma

  • Medulloblastoma With Extensive Nodularity

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, Somatic

  • Medulloblastoma, Desmoplastic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Mben

  • Medulloblastoma Desmoplastic

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-10993 Adavosertib Inhibitor 99.96% Phase 2
HY-145817A lunresertib Inhibitor 99.97% Phase 2
HY-182906 XL495 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (70)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132295 Azenosertib Inhibitor 99.96% Unkown
HY-13925 PD0166285 Inhibitor 99.46% Unkown
HY-147054 Zedoresertib Inhibitor 99.85% Unkown
HY-175749 BMS-986463 Degrader 98.63% Unkown
HY-N0819 Raddeanin A Inhibitor 98.68% Unkown
HY-18961 PD 407824 Inhibitor 99.00% Unkown
HY-122113 PD173952 Inhibitor 99.58% Unkown
HY-W1135319 SB-405483 99.33% Unkown
HY-133618 Pomalidomide-C3-adavosertib Degrader 99.84% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-147312 GSK-1520489A Inhibitor 99.83% Unkown
HY-108343 WEE1-IN-4 Inhibitor 99.70% Unkown
HY-103029 Bosutinib isomer Inhibitor 99.62% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-145817 (Rac)-lunresertib Inhibitor 99.72% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-173320 HEMTAC WEE1 degrader-1 Degrader 99.78% Unkown
HY-144999 LEB-03-146 98.08% Unkown
HY-138239 WEE1-IN-3 Inhibitor 98.64% Unkown
HY-168654 WEE1 degrader 1 Degrader 99.74% Unkown
HY-145664 Myt1-IN-1 Inhibitor 98.97% Unkown
HY-161880 WEE1-IN-10 Inhibitor / Unkown
HY-163697 WEE1-IN-7 Inhibitor 99.70% Unkown
HY-145666 Myt1-IN-3 Inhibitor 99.14% Unkown
HY-W070306 PDK1-IN-1 Inhibitor 99.95% Unkown
HY-169946 WEE1/PKMYT1-IN-1 Inhibitor 98.84% Unkown
HY-163490 PKMYT1-IN-1 Inhibitor 99.24% Unkown
HY-145817B (R)-lunresertib Inhibitor 99.87% Unkown
HY-180485 PROTAC D16-M1P2 Degrader / Unkown
HY-145665 Myt1-IN-2 Inhibitor / Unkown
HY-178190 WEE1-IN-13 Inhibitor / Unkown
HY-163491 PKMYT1-IN-2 Inhibitor / Unkown
HY-169946B WEE1/PKMYT1-IN-3 Inhibitor / Unkown
HY-178150 WEE1-IN-14 Inhibitor / Unkown
HY-182791 BAA-009 Inhibitor / Unkown
HY-133703A i-AZD1775 TFA Inhibitor / Unkown
HY-13925A PD0166285 dihydrochloride Inhibitor / Unkown
HY-143342 LEB-03-144 / Unkown
HY-176957 PKMYT1-IN-11 Inhibitor / Unkown
HY-183278 APO-50815 Inhibitor / Unkown
HY-157443 Myt1-IN-4 Inhibitor / Unkown
HY-175817 PKMYT1-IN-10 Inhibitor / Unkown
HY-183547 WEE1/PKMYT1-IN-4 Inhibitor / Unkown
HY-176283 Tubulin/LSD1-IN-1 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-160948 DB07006 Inhibitor / Unkown
HY-160530 WEE1-IN-6 Inhibitor / Unkown
HY-143340 LEB-03-145 / Unkown
HY-172759 PKMYT1-IN-9 Inhibitor / Unkown
HY-180484 PKMYT1-IN-12 Inhibitor / Unkown
HY-174448 WEE1-IN-12 Inhibitor / Unkown
HY-143343 LEB-03-153 / Unkown
HY-162849 PKMYT1-IN-3 Inhibitor / Unkown
HY-172807 p38α-IN-9 Inhibitor / Unkown
HY-168180 WEE1-IN-11 Inhibitor / Unkown
HY-176363 Adavosertib-C3-NH-Boc Inhibitor / Unkown
HY-180893 XH-30 Inhibitor / Unkown
HY-169946A WEE1/PKMYT1-IN-2 Inhibitor / Unkown
HY-175261 DHI1 Inhibitor / Unkown
HY-182790 BAA-065 Inhibitor / Unkown
HY-175819 PD-166285 Inhibitor / Unkown
HY-161871 WEE1-IN-8 Inhibitor / Unkown
HY-182433 CJM061 Inhibitor / Unkown
HY-161879 WEE1-IN-9 Inhibitor / Unkown
HY-159937 PKMYT1-IN-7 Inhibitor / Unkown
HY-162986 PKMYT1-IN-4 Inhibitor / Unkown
HY-162988 Myt1-IN-5 Inhibitor / Unkown
HY-N0819R Raddeanin A (Standard) / Unkown
HY-162987 PKMYT1-IN-6 Inhibitor / Unkown
HY-176853 Myt1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus WEE1 MGD MGI:103075
Felis catus WEE1 VGNC VGNC:67069
Bos taurus WEE1 VGNC VGNC:36930
Macaca mulatta WEE1 VGNC VGNC:78792
Canis familiaris WEE1 VGNC VGNC:48402
Rattus norvegicus WEE1 RGD RGD:1307895
Others WEE1 NCBI