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Adavosertib

(Synonyms: AZD1775; MK-1775)
67 Cited Publications
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Based on 67 publication(s) in Google Scholar

Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.

For research use only. We do not sell to patients.

  • Purity: 99.96%
  • CAS No.: 955365-80-7
  • Formula: C27H32N8O2
  • Molecular Weight:500.60
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Adavosertib Chemical Structure
    Adavosertib Chemical Structure
  • Experimental Validation Results for Adavosertib
  • Experimental Validation Results for Adavosertib
  • Experimental Validation Results for Adavosertib
CAS No.: 955365-80-7
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[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Adavosertib Chemical Structure
    Adavosertib Chemical Structure
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    Adavosertib purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 1;11(1):99. [Abstract]

    Customer Validation
     Representative immunoblots showing the expression of key proteins of the WEE1 pathway after treatment with AZD-1775 (IC50 for each cell line) for 24 h of the indicated cells lines. β-actin is used for loading normalization.

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    Adavosertib purchased from MedChemExpress. Usage Cited in: Cancer Res. 2017 Sep 1;77(17):4663-4672. [Abstract]

    Customer Validation
     Isogenic A549 or H2030 cells expressing full-length LKB1 or kinase-dead LKB1(KDLKB1) are treated with 1 μM AZD1775 or vehicle (DMSO) for 24 hours. Protein lysates are immunoblotted with the indicated antibodies. Actin was used as a loading control.

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    Adavosertib purchased from MedChemExpress. Usage Cited in: University of Bologna. 2016 Apr.

    Customer Validation
     In the blots B-/T-ALL cell lines are incubated for 24 hours with MK-1775 (IC50 value). The homogeneity of the protein loaded (40 μg) is determined using an internal control (β-actin).

  • Adavosertib