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Cat. No.: HY-162849

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PKMYT1-IN-3

PKMYT1-IN-3 (compound 8ma) is a potent and selective PKMYT1 inhibitor with an IC₅₀ value of 16.5 nM. PKMYT1-IN-3 has antitumor activity.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₆FN₅O₂
Molecular Weight:435.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PKMYT1-IN-3 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PKMYT1-IN-3 (compound 8ma) is a potent and selective PKMYT1 inhibitor with an IC₅₀ value of 16.5 nM. PKMYT1-IN-3 has antitumor activity^[1].

IC₅₀ & Target

PKMYT1

16.5 nM (IC₅₀)

All Wee1 Isoforms :

PKMYT1

Cellular Effect

Cell Line	Type	Value	Description	References
HCC1569	EC₅₀	116.8 nM Compound: 8ma	Inhibition of colony formation in CCNE1-amplified human HCC1569 cells incubated for 14 days by crystal violet staining based microplate reader assay Inhibition of colony formation in CCNE1-amplified human HCC1569 cells incubated for 14 days by crystal violet staining based microplate reader assay	[PMID: 39163619]
HCC1569	IC₅₀	0.25 μM Compound: 8ma	Antiproliferative activity against human HCC1569 cells incubated for 48 to 96 hrs by CCK-8 assay Antiproliferative activity against human HCC1569 cells incubated for 48 to 96 hrs by CCK-8 assay	[PMID: 39163619]
ZR-75-1	EC₅₀	>5 μM Compound: 8ma	Inhibition of colony formation in human ZR-75-1 cells incubated for 14 days by crystal violet staining based microplate reader assay Inhibition of colony formation in human ZR-75-1 cells incubated for 14 days by crystal violet staining based microplate reader assay	[PMID: 39163619]
ZR-75-1	IC₅₀	4.96 μM Compound: 8ma	Antiproliferative activity against human ZR-75-1 cells incubated for 48 to 96 hrs by CCK-8 assay Antiproliferative activity against human ZR-75-1 cells incubated for 48 to 96 hrs by CCK-8 assay	[PMID: 39163619]

Chemical Information

Molecular Weight 435.49
Formula C₂₄H₂₆FN₅O₂
SMILES

CC1=CC=C(C(C)=C1C2=C(C(C(N)=O)=CC(C3=CC(N4CC[C@H](C4)N)=NC(F)=C3)=C2)N)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15816-15836. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PKMYT1-IN-3

All Wee1 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PKMYT1-IN-3 Related Classifications

HY-162849 Related Classifications