1. Cell Cycle/DNA Damage
  2. Wee1
  3. WEE1-IN-3

WEE1-IN-3 

Cat. No.: HY-138239
Handling Instructions

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities.

For research use only. We do not sell to patients.

WEE1-IN-3 Chemical Structure

WEE1-IN-3 Chemical Structure

CAS No. : 2272976-28-8

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Description

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities[1].

IC50 & Target

IC50: <10 nM (Wee1 kinase)[1]

In Vitro

WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively[1]. WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΌΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

497.59

Formula

C₂₈H₃₁N₇O₂

CAS No.

2272976-28-8

SMILES

CN1CC2(CC2)C(C(C1)=C3)=CC=C3NC4=NC=C(C5=O)C(N(C6=CC=CC(C(C)(O)C)=N6)N5CC=C)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

WEE1-IN-3Wee1AnticancercellcycleInhibitorinhibitorinhibit

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