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DNA Repair Pathways & DDR

DNA Metabolism And Repair

The DNA damage response (DDR) is defined as a coordinated cellular network responsible for the recognition, signaling, and repair of DNA damage. To safeguard cellular viability and genome integrity, cells employ sophisticated DDR mechanisms, including non-homologous end joining (NHEJ), homologous recombination (HR), mismatch repair (MMR), nucleotide excision repair (NER), and base excision repair (BER). Inhibition of the DDR is anticipated to impair DNA repair processes, leading to the accumulation of persistent unrepaired DNA breaks, disruption of cell cycle progression, and enhanced sensitization of cancer cells to diverse DNA-damaging agents such as chemotherapeutic drugs. Research conducted over the past two decades has synthesised and tested hundreds of small-molecule inhibitors targeting key DDR proteins (e.g., ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia-and-Rad3-related protein (ATR), Wee1, etc.), with some demonstrating antitumour activity in human cancers [1] [3].

Currently, the development of novel DDR inhibitors and the exploration of combination therapy strategies are key research priorities. Wee1, a serine/threonine (Ser/Thr) protein kinase, serves as a critical regulator of cell cycle progression at the G2/M transition. Pharmacological inhibition of Wee1 abrogates this G2/M checkpoint, forcing cells to enter mitosis with damaged or under-replicated DNA. Several Wee1 inhibitors including Debio 0123, IMP7068, SC0191, and SY-4835 are currently undergoing solid tumor trials, with preliminary data showing promising results. In addition, distinct types of DDR inhibitors have been integrated into cancer treatment strategies, which include immunotherapy, chemotherapy, and radiotherapy, for the purpose of achieving combined therapeutic benefits [1] [2] [4].

The application of DDR inhibitors in cancer treatment holds immense promise while presenting significant challenges. Key challenges include managing severe side effects such as leukopenia and bone marrow toxicity, particularly when these inhibitors are combined with chemotherapy. Future efforts must focus on enhancing the specificity of DDR inhibitors through improved drug design to overcome existing limitations. This could pave the way for their widespread adoption in cancer treatment regimens [3].

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Cat. No. Product Name Information Application Publication
HY-17394 Cisplatin
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy.
DNA Alkylator/Crosslinker   Ferroptosis   Autophagy   Pyroptosis   Lipoxygenase  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Lung Squamous Cell Carcinoma   Large Cell Lung Carcinoma   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
837
HY-B0015 Paclitaxel
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
Microtubule/Tubulin   ADC Payloads   Apoptosis   Autophagy  
Lung Cancer   Prostate Cancer   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Cardiovascular Disease  
388
HY-17026 Gemcitabine
Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer.
Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis   Autophagy   Apoptosis   p38 MAPK  
Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection  
290
HY-50767 Palbociclib
Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
CDK  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Luminal Breast Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
249
HY-17371 Oxaliplatin
Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research.
DNA/RNA Synthesis   Apoptosis  
Prostate Cancer   Pancreatic Cancer   Digestive System Inflammation   Non-Small Cell Lung Cancer   Metastatic Breast Cancer  
232
HY-50767C Palbociclib hydrochloride
Palbociclib (PD 0332991) hydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib hydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells. Palbociclib hydrochloride can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
CDK  
Breast Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer  
229
HY-17565A Bleomycin hydrochloride
Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic.
DNA/RNA Synthesis   Antibiotic  
Pancreatic Cancer   Viral Infection  
212
HY-17565 Bleomycin sulfate
Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic.

Source: Streptomyces verticillus

DNA/RNA Synthesis   Antibiotic  
Pancreatic Cancer   Viral Infection  
212
HY-16561 Resveratrol
Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
DNA/RNA Synthesis   IKK   Autophagy   Mitophagy   Sirtuin   Apoptosis   Bacterial   Fungal   Antibiotic   Keap1-Nrf2  
Neurological, Eye or Ear Disease   Prostate Cancer   Liver Cancer   Bacterial Infection   Fungal Infection   Digestive System Inflammation   Glucose Metabolism   SARS-CoV-2 Infection   Obesity   Lung Fibrosis  
172
HY-D0815 Propidium Iodide
Propidium Iodide (PI) is a nuclear staining agent that stains DNA. Propidium Iodide is an analogue of ethidine bromide that emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. Propidium Iodide has a fluorescence wavelength of 493/617 nm and a wavelength of 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis (apoptosis) or necrosis (necrosis), and is often used in flow cytometry analysis.
Fluorescent Dye   DNA/RNA Synthesis  
160
HY-18982 Anisomycin
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic.

Source: Streptomyces griseolus

DNA/RNA Synthesis   JNK   Bacterial   Apoptosis   Antibiotic   Parasite  
Cancer   Digestive System Disease   Bacterial Infection   Parasitic Infection   Pain   Digestive System Inflammation  
155
HY-13753 Streptozotocin
Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells.

Source: Streptomyces achromogenes

DNA/RNA Synthesis   DNA Alkylator/Crosslinker   Autophagy   Bacterial   Antibiotic   Apoptosis  
Cancer   Infection  
150
HY-16297A Abemaciclib
Abemaciclib (LY2835219) is a selective and BBB-permeable CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
CDK  
Neurological, Eye or Ear Disease   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Non-Small Cell Lung Cancer   Luminal Breast Cancer   HER-2 Positive Breast Cancer   Metastatic Breast Cancer   Metastatic Prostate Cancer  
126
HY-13605 Cytarabine
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

Source: Xerocomus nigromaculatus

DNA/RNA Synthesis   Nucleoside Antimetabolite/Analog   HSV   Autophagy   Apoptosis   Endogenous Metabolite   Orthopoxvirus  
Neurological, Eye or Ear Disease   Digestive System Disease   Lung Cancer   Breast Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Digestive System Inflammation   Orthopoxvirus Infection   SARS-CoV-2 Infection  
105
HY-17393 Carboplatin
Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
DNA Alkylator/Crosslinker   Autophagy   DNA/RNA Synthesis  
95
HY-L004 Cell Cycle/DNA Damage Compound Library
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair. MCE owns a unique collection of 3,470 cell cycle/DNA damage-related compounds which can be used in the research of the same.

Signaling Pathway Targeting Libraries

93
HY-L024 Histone Modification Research Compound Library
A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases. MCE owns a unique collection of 924 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Signaling Pathway Targeting Libraries

85
HY-15777 Ribociclib
RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
CDK  
Neurological, Eye or Ear Disease   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Non-Small Cell Lung Cancer   Luminal Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
84
HY-L050 Ubiquitination Compound Library
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc. MCE offers a unique collection of 494 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Signaling Pathway Targeting Libraries

84
HY-14660 Dabrafenib
Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively.
Raf   CDK  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Non-Small Cell Lung Cancer  
83
HY-L135 Cancer Stem Cells Compound Library
With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on. Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment. MCE supplies a unique collection of 3,499 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

Compound Characteristic Classified Libraries

83
HY-L173 Anti-Ovarian Cancer Compound Library
Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer. MCE designs a unique collection of 2,934 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

Disease Focused Libraries

83
HY-L178 Radioprotector Library
Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells. MCE designs a unique collection of 3,020 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.

Compound Characteristic Classified Libraries

83
HY-L179 Radiosensitizer Library
Radiotherapy is a common treatment for various cancers, and more than 50% of cancer patients require radiotherapy during the disease treatment. With advances in radiation technology and a better understanding of tumor biology, the efficacy of radiation therapy has gradually improved, and more and more patients have benefited from it. However, even with the use of advanced radiotherapy techniques, there are still many malignant tumor cells with low sensitivity to radiation, leading to the radiation effect is not ideal. To solve this problem, radiosensitizers have received more and more attention. Radiosensitizer is a kind of drug that can enhance the radiosensitivity of tumor cells and improve the effect of radiotherapy. Radiation sensitizers act in a variety of ways, such as killing hypoxic cells, enhancing DNA damage, inhibiting DNA damage repair, and blocking cell cycle progression, making tumor cells more susceptible to radiation damage and death than surrounding normal cells. MCE designs a unique collection of 40 compounds with definite reported radiosensitization. It can be used for drug combination research in anti-cancer treatment.

Compound Characteristic Classified Libraries

83
HY-L244 High-Efficiency Gene Editing Compound Library
In this era of rapid advancement in gene-editing technology, the CRISPR-Cas system, with its powerful programmability, is leading a transformation in life sciences research. It enables efficient and precise targeted modification of an organism's genome, providing a robust tool for studying gene function, treating genetic diseases, and improving crop varieties. However, bottlenecks such as insufficient editing efficiency, low homologous directed repair efficiency, and potential off-target risks remain major challenges in achieving precise genetic modifications and developing gene therapies. To overcome these limitations, the MCE High-Efficiency Gene Editing Compound Library systematically includes 761 small molecules that are known or have the potential to enhance gene-editing efficiency. These compounds work by targeting and modulating the DNA damage repair network, mechanistically inhibiting non-homologous end joining, promoting homologous directed repair, or regulating chromatin states and cellular responses, thereby significantly optimizing editing outcomes. This library is suitable for developing "CRISPR-small molecule" combination therapy strategies, improving gene-editing efficiency, and providing a powerful tool for in-depth research into the mechanisms of DNA damage repair in gene editing.

Signaling Pathway Targeting Libraries

83
HY-12529 Ro-3306
Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively.
CDK   Apoptosis  
Digestive System Disease   Breast Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Digestive System Inflammation  
74
HY-10993 Adavosertib
Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.
Wee1  
Prostate Cancer   Pancreatic Cancer   SARS-CoV-2 Infection  
67
HY-10492 Dinaciclib
Dinaciclib (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.
CDK   Apoptosis  
Breast Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Digestive System Inflammation   SARS-CoV-2 Infection  
56
HY-10005 Flavopiridol
Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
CDK   Autophagy   HIV   Apoptosis  
Neurological, Eye or Ear Disease   Breast Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection  
54
HY-W250163 NAD+ lithium
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
50
HY-N0171A Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
Bacterial   Apoptosis   Reactive Oxygen Species (ROS)   MDM-2/p53   Caspase   PARP   MMP   Bcl-2 Family   HIF/HIF Prolyl-Hydroxylase   TNF Receptor   Interleukin Related   NF-κB   mTOR   Lactate Dehydrogenase   CDK   Glutathione Peroxidase   SOD  
Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
23
HY-13925 PD0166285
PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1.
Wee1   Apoptosis  
Digestive System Disease   Ovarian Cancer   Digestive System Inflammation  
9
HY-145817A lunresertib
lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC50 of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects.
Wee1  
9
HY-14392 5,6-Dichlorobenzimidazole riboside
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis.
CDK   Apoptosis  
Digestive System Disease   Breast Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Digestive System Inflammation  
9
HY-132295 Azenosertib
Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity.
Wee1  
Cancer  
5
HY-150279 PolQi2
PolQi2 is a PolΘ inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of PolΘ. PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9. PolQi2 can be used in gene editing research.
DNA/RNA Synthesis  
3
HY-126490 Phleomycin
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research.

Source: Streptoalloteichus hindustanus

Bacterial   Antibiotic   DNA/RNA Synthesis  
Cancer   Bacterial Infection  
2
HY-N6954 Garcinone C
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.
ATM/ATR   STAT   CDK   Hedgehog  
Inflammation or Immune System Disease   Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Obesity  
2
HY-B0255 Adefovir dipivoxil
Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer.
HBV   Orthopoxvirus   HSV   DNA/RNA Synthesis   ATM/ATR   CDK  
Breast Cancer   Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Orthopoxvirus Infection  
2
HY-138616 dGTP
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP.
DNA/RNA Synthesis   Nucleoside Antimetabolite/Analog  
Oxidative Stress and Inflammation  
1
HY-113064 Selenocystine
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment.
Endogenous Metabolite  
Cancer  
1
HY-15620 Methylproamine
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks.
DNA/RNA Synthesis  
1
HY-108343 WEE1-IN-4
WEE1-IN-4 (compound 15) is a pyrrolocarbazole-1,3(2H,6H)-dione derivative and Wee1 kinase inhibitor with an IC50 value of 11 nM.WEE1-IN-4 can be used for the research of cancer.
Wee1  
Cancer  
1
HY-122113 PD173952
PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis.
Src   Bcr-Abl   Apoptosis   Wee1  
Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Pain   Digestive System Inflammation   Alzheimer's Disease   Parkinson's Disease   Lung Fibrosis  
1
HY-N0819 Raddeanin A
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma.
Apoptosis   PI3K   Akt   ERK   mTOR   Wnt   β-catenin   Wee1   JNK   VEGFR   CDK  
Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Cancer Immunology   Digestive System Inflammation   Non-Small Cell Lung Cancer   Immunotherapy for Melanoma   Alzheimer's Disease  
1
HY-P86109 ATM Antibody (YA5801)
ATM Antibody (YA5801) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATM.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

1
HY-B0330DS (R)-Ofloxacin-d3
(R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria.
Isotope-Labeled Compounds   Bacterial   Antibiotic  
/
HY-P992066 Anti-Mouse DDR2 Antibody (DAB0065)
Anti-Mouse DDR2 Antibody (DAB0065) is a mAb that specifically targets mouse discoidin domain receptor DDR2 without cross-reacting with DDR1. Anti-Mouse DDR2 Antibody (DAB0065) binds to the extracellular domain of native mouse DDR2, induces endocytosis and lysosomal degradation of DDR2, and this process is independent of collagen binding. Anti-Mouse DDR2 Antibody (DAB0065) exhibits significant therapeutic effects in both the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis and the bleomycin (HY-108345)-induced mouse model of pulmonary fibrosis, effectively downregulating the mRNA expression of type I collagen Col1a1 and fibronectin Fn1. Anti-Mouse DDR2 Antibody (DAB0065) can be humanized and has the potential to be developed as a targeted agent for diseases such as idiopathic pulmonary fibrosis and renal fibrosis.

Species: Mouse

Discoidin Domain Receptor  
Lung Fibrosis  
/
HY-169248 DNA-PK-IN-15
DNA-PK-IN-15 (compound 6) is an inhibitor of DNA-PK with an IC50 value of 0.08 nM.
DNA-PK  
/
HY-153462 ATR-IN-24
ATR-IN-24 (Compound 1) is a ATR inhibitor. ATR-IN-24 has anticancer activity.
ATM/ATR  
Cancer  
/
HY-P10516 BRC4 peptide
BRC4 peptide is a specific peptide in BRCA2 protein that interacts with RAD51 protein to help repair broken DNA chains. BRC4 peptide can be used to study DNA repair mechanisms and cancer occurrence.
DNA/RNA Synthesis   RAD51  
/
HY-183488 R9-caPep
R9-caPep (RRRRRRRRRCCLGIPEQEY) is a cell-penetrating peptide derived from proliferating cell nuclear antigen (PCNA). R9-caPep selectively blocks the interactions between PCNA and FEN1, as well as between PCNA and LIGI, while preserving the binding of POLD3 to PCNA. R9-caPep interferes with DNA synthesis and homologous recombination-mediated double-strand DNA break repair, inducing S-phase arrest, DNA damage accumulation, and apoptosis. R9-caPep inhibits the growth of tumor volume and weight of neuroblastoma in nude mice. R9-caPep can be used in research related to neuroblastoma and triple-negative breast cancer.
Apoptosis   PARP  
Triple-Negative Breast Cancer  
/
HY-139609AS (1R,3r,5S)-Camonsertib-d3
(1R,3r,5S)-Camonsertib-d3 ((1R,3r,5S)-RP-3500-d3) is the deuterated-labeled (1R,3r,5S)-Camonsertib.
Isotope-Labeled Compounds  
/
HY-15794G Nemorubicin (GMP)
Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity.
G-quadruplex  
/
HY-144687 ATM Inhibitor-4
ATM Inhibitor-4 (compound 39) is a potent and selective ATM inhibitor, with an IC50 of 0.32 nM. ATM Inhibitor-4 shows stronger inhibition of PI3K kinases family. ATM Inhibitor-4 shows a full inhibition of mTOR at 1 μM. ATM Inhibitor-4 exhibits favorable metabolic stability.
ATM/ATR   PI3K   mTOR  
Cancer  
/
HY-153787 ATM Inhibitor-6
ATM inhibitor-6 (A-193) is a selective ATM kinase inhibitor. ATM inhibitor-6 can be used in cancer research.
ATM/ATR  
/
HY-136270S Gartisertib-d8
Gartisertib-d8 (VX-803-d8) is the deuterium labeled Gartisertib (HY-136270). Gartisertib (VX-803) is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity.
Isotope-Labeled Compounds   ATM/ATR  
/
HY-157490 PARP/HDAC-IN-1
PARP/HDAC-IN-1 (compound B102) is a potent dual inhibitor of PARP and HDAC. PARP/HDAC-IN-1 inhibits PARP1, PARP2 and HDAC1 with IC50s of 19.01, 2.13, 1690 nM, respectively.
PARP   HDAC  
Cancer  
/
HY-P990400 Anti-DDR1/CD167a Antibody
Anti-DDR1/CD167a Antibody is a CHO-expressed antibody that targets DDR1/CD167a. The Anti-DDR1/CD167a Antibody has a mouse IgG1 type heavy chain and a mouse κ type light chain, with a predicted molecular weight (MW) of 143.32 kDa. The isotype control for Anti-DDR1/CD167a Antibody can refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).

Species: Human

Discoidin Domain Receptor  
Inflammation or Immune System Disease  
/
HY-142931 ATM-IN-1
ATM-IN-1 is a potent inhibitor of ATM. ATM is located mainly in the nucleus and microsomes and is involved in cell cycle progression and in the cell cycle checkpoint response to DNA damage. ATM-IN-1 has the potential for the research of cancer and neurology diseases (extracted from patent WO2021139814A1, compound 3).
ATM/ATR  
Neurological, Eye or Ear Disease  
/
HY-P4161 KWWCRW
KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro.
DNA/RNA Synthesis  
Cancer  
/
HY-W016433S1 2-Aminofluorene-d11
2-Aminofluorene-d11 is the deuterium labeled 2-Aminofluorene. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis.
DNA/RNA Synthesis  
/
HY-N15249 4"-Isovalerylspiramycin I
4"-Isovalerylspiramycin I (Isovalerylspiramycin I) is a topoisomerase 1 (TOP1) inhibitor and an antitumor agent. 4"-Isovalerylspiramycin I directly binds to TOP1, suppresses DNA replication, and induces DNA damage. 4"-Isovalerylspiramycin I downregulates phosphorylated CHEK1 and the ATR/CHEK1 DNA damage repair pathway, blocks DNA repair, and augments DNA damage. 4"-Isovalerylspiramycin I suppresses proliferation, migration, and invasion of osteosarcoma cells. 4"-Isovalerylspiramycin I induces apoptosis and cell cycle arrest in osteosarcoma cells. 4"-Isovalerylspiramycin I exerts antibacterial activity against methicillin-resistant Staphylococcus aureus. 4"-Isovalerylspiramycin I can be used for the research of osteosarcoma, upper respiratory bacterial infections, and methicillin-resistant Staphylococcus aureus infection.

Source: S. spiramyceticus F21

Topoisomerase   DNA/RNA Synthesis   Checkpoint Kinase (Chk)   Apoptosis   Bacterial  
Cancer   Infection  
/
HY-P1790 Axltide
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases.
JAK  
Metabolic or Endocrine Disease  
/
HY-W016433S 2-Aminofluorene-13C
2-Aminofluorene-13C is the 13C labeled 2-Aminofluorene. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis.
DNA/RNA Synthesis  
/
HY-N0245R Theaflavin-3-gallate (Standard)
Theaflavin-3-gallate (Standard) is the analytical standard of Theaflavin-3-gallate. This product is intended for research and analytical applications. Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through p53-dependent pathways. Theaflavin-3-gallate induces DNA damage through ATM/Chk/p53 pathway.
Reference Standards   Apoptosis   MDM-2/p53   ATM/ATR   Checkpoint Kinase (Chk)  
Cancer  
/
HY-153755 ART6043
ART6043 (Polθ-IN-7) is an orally active, selective allosteric DNA polymerase θ (Polθ) inhibitor with an IC50 of 1.3 nM. ART6043 blocks microhomology-mediated end joining (MMEJ) by inhibiting the polymerase function of Polθ. ART6043 suppresses the survival of homologous recombination-deficient (HRD) cells and enhances the antitumor effects of PARP inhibitors. ART6043 can be used in studies of HRD tumors, including BRCA1-mutant triple-negative breast cancer, BRCA2-deficient colorectal cancer, RAD51C-deficient gastric cancer, and others.
DNA/RNA Synthesis  
Breast Cancer   Colorectal Cancer   Gastric Cancer  
/
HY-W766548 Floxuridine-13C,15N2
Floxuridine-13C,15N2 (5-Fluorouracil 2'-deoxyriboside-13C,15N2) is the 13C- and 15N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV.
Isotope-Labeled Compounds   CMV   DNA/RNA Synthesis   Nucleoside Antimetabolite/Analog   Bacterial   Apoptosis   HSV  
Cancer  
/
HY-N6954R Garcinone C (Standard)
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.
Reference Standards   ATM/ATR   STAT   CDK   Hedgehog  
Cancer   Inflammation or Immune System Disease  
/
HY-162692 DNA-PK-IN-14
DNA-PK-IN-14 (compound 78) is a potent, selective DNA-PK inhibitor with an IC50 value of 7.95 nM. DNA-PK-IN-14 has oral activity and has the potential to be a radiosensitizer for cancer treatment.
DNA-PK  
Cancer  
/
HY-132885 PARP/EZH2-IN-1
PARP/EZH2-IN-1 is a first-in-class dual PARP-1/EZH2 inhibitor with IC50 values of 6.87 nM and 36.51 nM, respectively. PARP/EZH2-IN-1 induces autophagy in cancer cells and shows potent antiproliferative activity in BRCA wild-type triple-negative breast cancer cells.
PARP   Histone Methyltransferase   Autophagy  
Triple-Negative Breast Cancer  
/
HY-N19343 Cistanoside C
Cistanoside C is a phenylpropanoid glycoside with free radical scavenging, DNA repair and DNA minor groove binding activities. Cistanoside C scavenges hydrated electrons and hydroxyl radicals. Cistanoside C inhibits the proliferation of cancer cells. Cistanoside C can be used in research related to leukemia, liver cancer, lung adenocarcinoma and gastric adenocarcinoma.
Biochemical Assay Reagents  
Liver Cancer   Leukemia/Lymphoma/Myeloma  
/
HY-W353258R Moxifloxacin hydrochloride monohydrate (Standard)
Moxifloxacin hydrochloride (BAY 12-8039) monohydrate (Standard) is the analytical standard of Moxifloxacin hydrochloride monohydrate. This product is intended for research and analytical applications. Moxifloxacin hydrochloride monohydrate is a blood-brain barrier-permeable, orally active topoisomerase II/IV inhibitor and a fluoroquinolone antibiotic. Moxifloxacin hydrochloride monohydrate disrupts bacterial DNA replication, transcription, repair and chromosome segregation processes. Moxifloxacin hydrochloride monohydrate exhibits activity against Gram-positive bacteria, Gram-negative bacteria, anaerobes, atypical pathogens, drug-resistant respiratory pathogens, Mycobacterium tuberculosis, mycoplasmas and Ureaplasma urealyticum.
Reference Standards   Bacterial   Topoisomerase   Antibiotic  
Bacterial Infection  
/
HY-142924 ATR-IN-8
ATR-IN-8 is a potent inhibitor of ATR. ATR is a key enzyme in the homologous recombination repair pathway and belongs to the PIKK family. ATR-IN-8 has the potential for the research of cancer diseases (extracted from patent WO2021143821A1, compound 3).
ATM/ATR  
/
HY-N7147 Irisquinone
Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks.
Others  
Cancer  
/
HY-D2941 BGAF
BGAF (SNAP-AF) is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment.
Fluorescent Dye  
/
HY-147565 ATR-IN-13
ATR-IN-13 (compound A9) is a potent ATR kinase inhibitor, with an IC50 of 2 nM. ATR-IN-13 can be used for ATR kinase mediated diseases research, such as proliferative diseases and cancer.
ATM/ATR  
Cancer  
/
HY-15772GL Osimertinib (GMP Like)
Osimertinib (AZD-9291; Mereletinib) GMP Like is the GMP Like level of Osimertinib (HY-15772). GMP Like small molecules works appropriately as an auxiliary reagent for cell research manufacture. Osimertinib GMP Like is an inhibitor that selectively targets EGFRT790M and activated EGFR mutants. Osimertinib GMP Like exerts multiple anti-tumor mechanisms, including radiosensitization, induction of apoptosis and ferroptosis, as well as inhibition of cancer stemness. Osimertinib GMP Like suppresses EGFR nuclear translocation and downstream survival signaling pathways, significantly reduces cell viability and lipid droplet content, and also exerts synergistic effects with radiotherapy or specific targeted agents to effectively overcome drug resistance and radioresistance. Formulations of Osimertinib GMP Like modified with liposomes or iRGD enable sustained release, tumor-specific accumulation, and breakthrough of the blood-brain barrier limitation. Osimertinib GMP Like can be used in research related to radioresistant glioblastoma and non-small cell lung cancer.
EGFR   Apoptosis   Ferroptosis  
Cancer  
/
HY-174989 ATM-IN-2
ATM-IN-2 is a selective and orally active ATM inhibitor with an IC50 of 4 nM. ATM-IN-2 exhibits excellent kinase selectivity (>700-fold over PIKK family members). ATM-IN-2 exerts its anti-tumor effect by inhibiting ATM phosphorylation and the downstream signaling pathways (p53, H2AX), and promotes cell apoptosis. ATM-IN-2 can be used for the study of chemosensitizer candidate such as colon cancer.
ATM/ATR   Apoptosis  
Cancer  
/
HY-P990873 Anti-BRCA1 Antibody (BR64)
Anti-BRCA1 Antibody (BR64) is a kind of mouse IgG1 κ chimeric antibody, targeting to human BRCA1. Anti-BRCA1 Antibody (BR64) reacts with BRCA1 (Breast cancer susceptibility gene 1) involved in tumor suppression, transcription, genomic stability, DNA repair and recombination. Anti-BRCA1 Antibody (BR64) can be used for the detections of immunofluorescence, western blot, and immunoprecipitation in cancer, such as breast and ovarian cancer.

Species: Human

DNA/RNA Synthesis  
Cancer  
/
HY-15772G Osimertinib (GMP)
Osimertinib (AZD-9291; Mereletinib) GMP is the GMP level of Osimertinib (HY-15772). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Osimertinib GMP is an inhibitor that selectively targets EGFRT790M and activated EGFR mutants. Osimertinib GMP exerts multiple anti-tumor mechanisms, including radiosensitization, induction of apoptosis and ferroptosis, as well as inhibition of cancer stemness. Osimertinib GMP suppresses EGFR nuclear translocation and downstream survival signaling pathways, significantly reduces cell viability and lipid droplet content, and also exerts synergistic effects with radiotherapy or specific targeted agents to effectively overcome drug resistance and radioresistance. Formulations of Osimertinib GMP modified with liposomes or iRGD enable sustained release, tumor-specific accumulation, and breakthrough of the blood-brain barrier limitation. Osimertinib GMP can be used in research related to radioresistant glioblastoma and non-small cell lung cancer.
EGFR   Apoptosis   Ferroptosis  
Cancer  
/
HY-N12959 5,4'-Dihydroxy-6,8-dimethoxy-7-O-rhamnosyl flavone
5,4'-Dihydroxy-6,8-dimethoxy-7-O-rhamnosyl flavone (DDR) is an anticancer agent that can be extracted from Indigofera ovata. 5,4'-Dihydroxy-6,8-dimethoxy-7-O-rhamnosyl flavone can inhibit the PI3K/AKT and NF-кB pathways, inhibit the invasion and migration of cancer cells, and has anticancer activity.
PI3K   NF-κB   Akt  
/
HY-N7046R Silybin B (Standard)
Silybin (Silibinin B) (Standard) is the analytical standard of Silybin B (HY-N7046). This product is intended for research and analytical applications. Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator, that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity.
Reference Standards   JNK   Amyloid-β   p38 MAPK   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-W777340 Gimeracil-13C3
Gimeracil-13C3 (Gimestat-13C3) is the 13C-labeled Gimeracil (HY-17469). Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD).
Isotope-Labeled Compounds   Dihydropyrimidine Dehydrogenase (DPD)   DNA/RNA Synthesis  
Cancer  
/
HY-N7059A Lactobionic acid calcium dihydrate
Lactobionic acid calcium dihydrate is a biomimetic acid found in Caspian yogurt, chemically composed of gluconic acid bonded to galactose. Lactobionic acid calcium dihydrate has antioxidant, antimicrobial, chelating, stabilizer, acidulant and humectant properties. Lactobionic acid calcium dihydrate can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid calcium dihydrate can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid calcium dihydrate inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA.
Biochemical Assay Reagents   Bacterial   Reactive Oxygen Species (ROS)  
Infection  
/
HY-P10434 BRC4wt
BRC4wt (BRC4 repeat motif) is part of the BRACA2 tumor suppressor protein, which exhibits inhibitory activity against interaction of the BRACA2 protein with RAD51, and is involved in the repair of DNA damage.
Others  
/
HY-P10574 Phosphorylated CHKtide
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs).
Checkpoint Kinase (Chk)  
Cancer  
/
HY-B0255R Adefovir dipivoxil (Standard)
Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer.
Reference Standards   HBV   Reverse Transcriptase   Orthopoxvirus   Endogenous Metabolite  
Cancer   Infection  
/
HY-17469S Gimeracil-13C3,15N
Gimeracil-13C3,15N (Gimestat-13C3,15N) is 13C and 15N labeled Gimeracil. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD).
Isotope-Labeled Compounds  
Cancer  
/
HY-W011425A NTPO trisodium
NTPO trisodium is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO trisodium are abrogated by base excision repair (BER) but not nucleotide excision repair (NER).
Others  
Cancer  
/
HY-N18301 Americanin A
Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer.
ATM/ATR   Checkpoint Kinase (Chk)   MDM-2/p53   E1/E2/E3 Enzyme   CDK   Mitosis   Reactive Oxygen Species (ROS)   Apoptosis  
Colorectal Cancer  
/
HY-W000838R 1-Hydroxyanthraquinone (Standard)
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect.
Reference Standards   DNA/RNA Synthesis  
Cancer  
/
HY-13599S2 Cladribine-15N
Cladribine-15N (2-Chloro-2′-deoxyadenosine-15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds   Adenosine Deaminase   Apoptosis  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-13599S Cladribine-d4
Cladribine-d4 (2-Chloro-2′-deoxyadenosine-d4) is deuterium labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-N0819R Raddeanin A (Standard)
Raddeanin A (Standard) is the analytical standard of Raddeanin A (HY-N0819). This product is intended for research and analytical applications. Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma.
Reference Standards   Apoptosis   PI3K   Akt   ERK   mTOR   Wnt   β-catenin   Wee1   JNK   VEGFR   CDK  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-114169S WRG-28-d5
WRG-28-d5 is the deuterium labeled WRG-28(HY-114169).WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic
Isotope-Labeled Compounds  
Cancer  
/
HY-P5265 Tetrapeptide
Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. Tetrapeptide diminishes DNA damage by reducing the production of reactive oxidative species and enhancing repair of DNA photoproducts.
DNA/RNA Synthesis  
Metabolic or Endocrine Disease  
/
HY-N7046S Silybin B-d3
Silybin B-d3 (Silibinin B-d3) is a deuterated Silybin B (HY-N7046). Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator, that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity.
Isotope-Labeled Compounds   JNK   Apoptosis   Amyloid-β   p38 MAPK  
Cancer   Neurological, Eye or Ear Disease  
/
HY-111451S Tuvusertib-d3
Tuvusertib-d3 (M1774-d3) is the deuterium labeled Tuvusertib (HY-111451). Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor with a Ki value below 1 μΜ.
Isotope-Labeled Compounds   ATM/ATR  
Cancer  
/
HY-125576 Griselimycin
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria.
Bacterial  
Bacterial Infection  
/
HY-N8840 Laricitrin
Laricitrin is a natural product with multiple biological activities. Laricitrin inhibits the phosphorylation and DNA-binding activity of STAT3, and downregulates the expression of IL-10. Laricitrin acts as an immunomodulator to regulate the differentiation, maturation and function of dendritic cells (DCs). Laricitrin inhibits the migration and invasion of lung cancer cells, and ameliorates lung cancer progression. Laricitrin can be used in research related to hypertension and lung cancer.
STAT   Interleukin Related  
Lung Cancer   Hypertension  
/
HY-133124 PARP/PI3K-IN-1
PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound targeted against a wide range of oncologic diseases.
PARP   PI3K   Apoptosis  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
/
HY-NP131 Recombinant Humanized Type III Collagen (10.4kDa)
Recombinant Humanized Type III Collagen 10.4kDa is a novel biomaterial that have anticancer effects. Recombinant Humanized Type III Collagen 10.4kDa activates discoidin domain receptor 1 (DDR1), and thus inhibits autophagy, proliferation, and migration of cancer cells, and induces apoptosis.
Discoidin Domain Receptor   Apoptosis   Autophagy  
/
HY-W070306 PDK1-IN-1
PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor. PDK1-IN-1 is also useful as inhibitor of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. PDK1-IN-1 selectively inhibits microtubule affinity regulating kinase (MARK). PDK1-IN-1 can be used for researches of myeloproliferative disorders, cancer and Alzheimer's disease.
PDK-1   FGFR   Wee1   MARK  
Lung Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Alzheimer's Disease   Obesity  
/
HY-171421 Polθ-IN-8
Polθ-IN-8 (example 77) is a DNA polymerase theta (Polθ) inhibitor with an c of <100 nM for Polθ ATPase activity. Polθ-IN-8 can be used to study diseases related to Polθ activity (such as cancer).
DNA/RNA Synthesis  
Cancer  
/
HY-116887R N6-Methyladenine (Standard)
N6-Methyladenine (Standard) is the analytical standard of N6-Methyladenine (HY-116887). This product is intended for research and analytical applications. N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases.
Endogenous Metabolite   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis   Reference Standards  
Cancer  
/
HY-N11709 Theasaponin E1
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections.
Apoptosis   VEGFR   ATM/ATR   PTEN   Akt   mTOR   HIF/HIF Prolyl-Hydroxylase   NF-κB   Notch   Cholinesterase (ChE)   Amyloid-β   γ-secretase   Ferroptosis   Fungal  
Ovarian Cancer   Fungal Infection   Alzheimer's Disease   Obesity  
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HY-101566S Elimusertib-d3
Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity.
ATM/ATR  
Cancer  
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HY-161880 WEE1-IN-10
WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC50 of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1.
Wee1  
Cancer  
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HY-163134 DNA-PK-IN-12
DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM. DNA-PK-IN-12 inhibits cell growth and Hct116 cell colony formation with the IC50 of 33.28 μM, and shows antitumor activity in vivo.
DNA-PK  
Pancreatic Cancer   Obesity  
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HY-163697 WEE1-IN-7
WEE1-IN-7 (compound 12h) is a potent and orally activeWEE1 inhibitor with an IC50 value of 2.1 nM. WEE1-IN-7 induces apoptosis and cell cycle arrest at the S phase. WEE1-IN-7 shows antitumor activity.
Wee1   Apoptosis  
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HY-17026S Gemcitabine-13C,15N2
antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
Isotope-Labeled Compounds   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis   Autophagy   Apoptosis  
Cancer  
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HY-118921 Ovatodiolide
Ovatodiolide is a compound that can be isolated from Anisomeles indica. Ovatodiolide has anti-bacterial and anti-inflammatory properties. Ovatodiolide also has anti-cancer activity that induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways.
Apoptosis  
Cancer   Inflammation or Immune System Disease  
/
HY-138239 WEE1-IN-3
WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities.
Wee1  
Cancer  
/
HY-N6576 Hellebrigenin
Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway (ERK, p38, JNK) and XIAP, and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways (such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage), downregulate anti-apoptotic proteins (Bcl-2, Bcl-xL) and upregulate pro-apoptotic proteins (Bax, Bak). Hellebrigenin can also induce DNA double-strand breaks to activate the ATM pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers.

Source: toad

p38 MAPK   IAP   Caspase   JNK   Apoptosis   ERK   PARP  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
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HY-17364S Temozolomide-d3
Temozolomide-d3 is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects.
DNA Alkylator/Crosslinker   Autophagy   Apoptosis  
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HY-W076740 8-Bromoadenine
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium.
DNA/RNA Synthesis   Biochemical Assay Reagents  
/
HY-P5429 DNA-PK Substrate
DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
Others  
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HY-W000838 1-Hydroxyanthraquinone
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect.
DNA/RNA Synthesis  
Cancer  
/
HY-116887 N6-Methyladenine
N6-Methyladenine is a DNA epigenetic modification that involves the addition of a methyl group to the sixth position of adenine. N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases.
Endogenous Metabolite   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
Lung Cancer   Leukemia/Lymphoma/Myeloma   Glucose Metabolism  
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HY-NP175 Collagen (bovine skin)
Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development.
Biochemical Assay Reagents   Integrin   Discoidin Domain Receptor  
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HY-N7046 Silybin B
Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity.
Amyloid-β   p38 MAPK   JNK   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
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HY-B0003S Gemcitabine-13C,15N2 hydrochloride
Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
Apoptosis   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis   Autophagy  
Cancer  
/
HY-P10280 ATR kinase substrate peptide
ATR kinase substrate peptide (ASELPASQPQPFSAKKK) is a peptide substrate for ATR protein kinase and can be used to detect ATR kinase activity.
ATM/ATR  
Cancer  
/
HY-W1135319 SB-405483
SB-405483 is a CRBN orthosteric ligand bindign enhancer. SB-405483 potentiates degradation of CRBN substrates including CK1α, Wee1, IKZF1/3. SB-405483 stabilizes CRBN and reduces CRBN autoubiquitination. SB-405483 can be used for the research of cancer, such as multiple myeloma and acute myeloid leukemia.
Casein Kinase   Wee1   IKZF Family  
Multiple Myeloma  
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HY-18961 PD 407824
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.
Checkpoint Kinase (Chk)   Wee1  
Cancer   Inflammation or Immune System Disease   Lung Fibrosis  
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HY-175749 BMS-986463
BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader. BMS-986463 significantly inhibits tumor regression and reduces the level of phospho-CDK2. BMS-986463 can be used for advanced malignant solid tumors like non-small cell lung cancer (NSCLC) research.
Molecular Glues   Wee1  
Respiratory Disease   Non-Small Cell Lung Cancer  
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HY-P991049 Atrosimab
Atrosimab is an Fv-Fc1K fusion protein with an EC50 value of 0.37 nM against humans. Atrosimab inhibits TNF-induced TNFR1 activation, release of IL-6 and IL-8, and cell death, and alleviates neuroinflammation. Atrosimab is applicable to research related to inflammatory diseases, neurodegenerative diseases, acute and chronic inflammation, experimental arthritis, non-alcoholic steatohepatitis, and experimental autoimmune encephalomyelitis.

Species: Human

TNF Receptor  
Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis   Fatty Liver Disease  
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HY-N0245 Theaflavin-3-gallate
Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through p53-dependent pathways. Theaflavin-3-gallate induces DNA damage through ATM/Chk/p53 pathway.
Apoptosis   MDM-2/p53   ATM/ATR   Checkpoint Kinase (Chk)  
Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Digestive System Inflammation   Parkinson's Disease  
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HY-147054 Zedoresertib
Zedoresertib (Debio 0123) is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. Zedoresertib inhibits phospho-CDC2. Zedoresertib abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. Zedoresertib can be used for researching anticancer.
Wee1   CDK  
Breast Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
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HY-P991272 ATR-107
ATR-107 (PF-05230900) is a humanized monoclonal antibody inhibitor that targets the interleukin-21 receptor (IL-21R). The Ka value of ATR-107 is 2-4 nM in cynomolgus monkeys, 16 nM in mice, and 71 nM in rats. ATR-107 can be used in research related to systemic lupus erythematosus and air pouch inflammation.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
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HY-P73846 Ku70-Ku80 Heterodimer Protein, Human (sf9, His)
Ku70 is a single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA nonhomologous end joining (NHEJ) and is central to double-strand break repair and V(D)J recombination. As a DNA helicase II complex, it has a cell cycle-dependent preference for double-stranded DNA fork ends in the 3'-5' direction, recognizing and binding to broken DNA ends during NHEJ, protecting them from resection. Ku70-Ku80 Heterodimer Protein, Human (sf9, His) is a recombinant protein dimer complex containing human-derived Ku70-Ku80 Heterodimer protein, expressed by Sf9 insect cells , with N-His labeled tag. Ku70-Ku80 Heterodimer Protein, Human (sf9, His), has molecular weight of ~70 & 85 kDa, respectively.

Species: Human; Source: Sf9 insect cells

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HY-P71479 AlkB Protein, E.coli (Myc, His-SUMO)
AlkB Protein, E.coli (Myc, His-SUMO) is a protein found in E. coli, plays a major role in oxidative dealkylation processes.

Species: E.coli; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P75305 DDR1 Protein, Human (HEK293, His)
The DDR1 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that tightly regulates cell attachment and affects extracellular matrix processes. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC, activating MAP kinase. DDR1 Protein, Human (HEK293, His) is the recombinant human-derived DDR1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

CD Antigens Receptor Proteins Enzymes & Regulators Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR1/CD167a DDR Family

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HY-P701727 Wee1 Protein, Human (sf9, His)
Wee1 Protein acts as a crucial negative regulator of the G2 to M transition, ensuring nuclear protection by phosphorylating CDK1 on 'Tyr-15' and inactivating the cyclin B1-CDK1 complex. Its peak activity in G2 phase decreases as cells progress into M phase, with dynamic regulation, increased phosphorylation during S and G2 phases, and diminished levels during M/G1 phase transition potentially due to degradation. Wee1 Protein, Human (sf9, His) is the recombinant human-derived Wee1 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins Other Kinases WEE WEE1

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HY-P7523 APE Protein, Human
APE Protein, Human is an approximately 40.0 kDa protein expressed by E. coli expression system. Human APE plays an important role in BER by acting downstream of DNA glycosylases.

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P7521A TEM8/ANTXR1 Protein, Human (HEK293, His)
The TEM8/ANTXR1 protein is multifunctional in cell attachment and migration, interacting with extracellular matrix proteins and the actin cytoskeleton. This binding mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeletal reorganization and cell spreading, which is critical for cell structure and movement. TEM8/ANTXR1 Protein, Human (HEK293, His) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293, with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P71512 RecO Protein, E.coli (His-SUMO)
RecO protein, a crucial participant in DNA repair and the RecF pathway, operates as a monomer, contributing to the intricate choreography of DNA repair mechanisms and facilitating recombination. Its monomeric form underscores its singular involvement, highlighting its significance in orchestrating cellular responses to DNA damage and recombination. RecO Protein, E.coli (His-SUMO) is the recombinant E. coli-derived RecO protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

Species: E.coli; Source: E. coli

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HY-P72673 DDR2 Protein, Mouse (HEK293, His)
The DDR2 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that critically regulates cell differentiation, extracellular matrix remodeling, migration, and proliferation.DDR2 is crucial for bone development.It affects osteoblast differentiation and chondrocyte maturation through the MAP kinase signaling pathway and activates the transcription factor RUNX2.DDR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins Enzymes & Regulators Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR Family DDR2

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HY-P703091 BRCA1 Protein, Human
BRCA1 Protein, Human is the recombinant human-derived BRCA1, expressed by E. coli, with tag free labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P703129 XRCC6 Protein, Human (Flag)
XRCC6 Protein, Human (Flag) is the recombinant human-derived XRCC6, expressed by E. coli , with Flag labeled tag. ,

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P77639 DDR1 Protein, Mouse (HEK293, His)
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR1, expressed by HEK293, with C-6*His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens Receptor Proteins Enzymes & Regulators Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR1/CD167a DDR Family

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HY-P701729 WEE2 Protein, Human (Active, sf9, His, GST)
WEE2 protein is an oocyte-specific tyrosine kinase that plays an important role in meiosis during prophase I and metaphase II. It maintains meiotic arrest at the germinal vesicle (GV) stage by phosphorylating CDK1 at 'Tyr-15', inhibiting CDK1 activity and preventing reentry. WEE2 Protein, Human (sf9, His, GST) is the recombinant human-derived WEE2 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins Other Kinases WEE WEE2

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HY-P75297 DDR2 Protein, Rat (HEK293, His)
The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rat (HEK293, His) is the recombinant rat-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag.

Species: Rat; Source: HEK293

Receptor Proteins Enzymes & Regulators Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR Family DDR2

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HY-P77226 TEM8/ANTXR1 Protein, Human (HEK293, Fc)
The TEM8/ANTXR1 protein is multifunctional in cell attachment and migration, interacting with extracellular matrix proteins and the actin cytoskeleton. This binding mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeletal reorganization and cell spreading, which is critical for cell structure and movement. TEM8/ANTXR1 Protein, Human (HEK293, Fc) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

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HY-P71489 RecF/UvrF Protein, E.coli (His-SUMO)
RecF/UvrF Protein is crucial in DNA metabolism, essential for DNA replication and inducing the SOS response. Its preference for binding to single-stranded DNA underscores its role in DNA maintenance. RecF also displays an affinity for ATP binding, emphasizing its involvement in regulating DNA-related functions. RecF/UvrF Protein, E.coli (His-SUMO) is the recombinant E. coli-derived RecF/UvrF protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

Species: E.coli; Source: E. coli

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HY-P75301 DDR1 Protein, Mouse (Active, sf9, His-GST)
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived DDR1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Mouse; Source: Sf9 insect cells

CD Antigens Receptor Proteins Enzymes & Regulators Kinases Epithelial cell CD Proteins Receptor Tyrosine Kinases Transferases (EC 2) Protein Tyrosine Kinases TK DDR1/CD167a DDR Family

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HY-P73803 MSH2 Protein, Human (sf9, His-GST)
MSH2 protein is a key component of the DNA mismatch repair system, which can recognize and bind DNA mismatches to initiate repair. MSH2 forms heterodimers MutS α and MutS β that target various mismatches. MSH2 Protein, Human (sf9, His-GST) is the recombinant human-derived MSH2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P75304 DDR1 Protein, Human (Active, sf9, His-GST)
The DDR1 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that tightly regulates cell attachment and affects extracellular matrix processes. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC, activating MAP kinase. DDR1 Protein, Human (sf9, His-GST) is the recombinant human-derived DDR1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

CD Antigens Receptor Proteins Enzymes & Regulators Kinases Epithelial cell CD Proteins Receptor Tyrosine Kinases Transferases (EC 2) Protein Tyrosine Kinases TK DDR1/CD167a DDR Family

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HY-P75299 DDR1 Protein, Rat (HEK293, His)
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation.Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion.DDR1 Protein, Rat (HEK293, His) is the recombinant rat-derived DDR1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Rat; Source: HEK293

CD Antigens Receptor Proteins Enzymes & Regulators Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR1/CD167a DDR Family

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HY-P75300 DDR1 Protein, Rat (HEK293, hFc)
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation.Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion.DDR1 Protein, Rat (HEK293, hFc) is the recombinant rat-derived DDR1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Rat; Source: HEK293

CD Antigens Receptor Proteins Enzymes & Regulators Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR1/CD167a DDR Family

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HY-P75302 DDR1 Protein, Mouse (HEK293, His, solution)
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived DDR1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens Receptor Proteins Enzymes & Regulators Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR1/CD167a DDR Family

/
HY-P75303 DDR1 Protein, Mouse (HEK293, Fc)
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived DDR1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Mouse; Source: HEK293

CD Antigens Receptor Proteins Enzymes & Regulators Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases DDR1/CD167a DDR Family

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HY-P701726 Wee1 Protein, Human (Active, sf9)
Wee1 Protein acts as a crucial negative regulator of the G2 to M transition, ensuring nuclear protection by phosphorylating CDK1 on 'Tyr-15' and inactivating the cyclin B1-CDK1 complex. Its peak activity in G2 phase decreases as cells progress into M phase, with dynamic regulation, increased phosphorylation during S and G2 phases, and diminished levels during M/G1 phase transition potentially due to degradation. Wee1 Protein, Human (sf9) is the recombinant human-derived Wee1 protein, expressed by sf9 insect cells , with tag free.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins Other Kinases WEE WEE1

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HY-P703439 RAD51 Protein, Pyrococcus furiosus (del R288-G301)
RAD51 Protein, Pyrococcus furiosus (del R288-G301) is the recombinant RAD51, expressed by E. coli , with tag Free labeled tag.

Species: Others; Source: E. coli

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HY-P703440 RAD51 Protein, Pyrococcus furiosus
RAD51 Protein, Pyrococcus furiosus is the recombinant RAD51, expressed by E. coli , with tag Free labeled tag. ,

Species: Others; Source: E. coli

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HY-P705240 TEM8/ANTXR1 Protein, Human (Biotinylated, HEK293, His-Avi)
The TEM8/ANTXR1 protein is multifunctional in cell attachment and migration, interacting with extracellular matrix proteins and the actin cytoskeleton. This binding mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeletal reorganization and cell spreading, which is critical for cell structure and movement. TEM8/ANTXR1, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293, with N-Avi labeled tag.

Species: Human; Source: HEK293

Biotinylated Proteins

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HY-P705896 Wee1 Protein, Human (Biotinylated, sf9, Avi)
Wee1 Protein acts as a crucial negative regulator of the G2 to M transition, ensuring nuclear protection by phosphorylating CDK1 on 'Tyr-15' and inactivating the cyclin B1-CDK1 complex. Its peak activity in G2 phase decreases as cells progress into M phase, with dynamic regulation, increased phosphorylation during S and G2 phases, and diminished levels during M/G1 phase transition potentially due to degradation. Wee1, Human (Biotinylated, sf9, Avi) is the recombinant human-derived Wee1 protein, expressed by sf9 insect cells, with N-His;N-GST labeled tag.

Species: Human; Source: sf9 insect cells

Enzymes & Regulators Kinases Biotinylated Proteins Transferases (EC 2) Other Kinases WEE WEE1

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HY-P706113 Wee1 Protein, Human (Active, 432a.a, sf9, His-GST)
Wee1 Protein acts as a crucial negative regulator of the G2 to M transition, ensuring nuclear protection by phosphorylating CDK1 on 'Tyr-15' and inactivating the cyclin B1-CDK1 complex. Its peak activity in G2 phase decreases as cells progress into M phase, with dynamic regulation, increased phosphorylation during S and G2 phases, and diminished levels during M/G1 phase transition potentially due to degradation. Wee1, Human (Active, 432a.a, sf9, His-GST) is the recombinant human-derived Wee1 protein, expressed by Sf9 insect cells, with N-6*His;N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Other Kinases WEE WEE1

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HY-P706186 Wee1 Protein, Human (Active, sf9, His-GST)
Wee1 Protein acts as a crucial negative regulator of the G2 to M transition, ensuring nuclear protection by phosphorylating CDK1 on 'Tyr-15' and inactivating the cyclin B1-CDK1 complex. Its peak activity in G2 phase decreases as cells progress into M phase, with dynamic regulation, increased phosphorylation during S and G2 phases, and diminished levels during M/G1 phase transition potentially due to degradation. Wee1, Human (Active, sf9, His-GST) is the recombinant human-derived Wee1 protein, expressed by Sf9 insect cells, with N-6*His;N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Kinases Other Kinases WEE WEE1

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HY-P80453 Phospho-ATM (S1981) Antibody (YA223)
Phospho-ATM (S1981) Antibody (YA223) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ATM (S1981).

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P80023 ATM Antibody (YA597)
ATM Antibody (YA597) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATM.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84716 TNFRSF25 Antibody (YA4413)
TNFRSF25 Antibody (YA4413) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TNFRSF25.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P87894 ATR Antibody (YA7579)
ATR Antibody (YA7579) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ATR.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87805 Phospho-ATM (Ser1981) Antibody (YA7490)
Phospho-ATM (Ser1981) Antibody (YA7490) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-ATM (Ser1981).

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P81314A XRCC1 Antibody (YA1059)
XRCC1 Antibody (YA1059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XRCC1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83436 Phospho-ATM (Ser1981) Antibody (YA3181)
Phospho-ATM (Ser1981) Antibody (YA3181) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ATM (Ser1981).

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P87704 DDR1 Antibody (YA7389)
DDR1 Antibody (YA7389) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to DDR1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87147 Wee1 Antibody (YA6840)
Wee1 Antibody (YA6840) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Wee1.

Host: Rabbit; Reactivity: Human, Monkey

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80661 ERCC1 Antibody (YA770)
ERCC1 Antibody (YA770) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERCC1.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83622 DDR2 Antibody (YA3367)
DDR2 Antibody (YA3367) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DDR2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81337A XRCC4 Antibody (YA1082)(PBS only)
XRCC4 Antibody (YA1082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC4.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P810940 XRCC2 Antibody
XRCC2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to XRCC2.

Host: Rabbit; Reactivity: Human, Monkey

Polyclonal Antibodies Primary Antibodies

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HY-P81314 XRCC1 Antibody (YA1058)
XRCC1 Antibody (YA1058) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P81337 XRCC4 Antibody (YA1082)
XRCC4 Antibody (YA1082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC4.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P82027 PMS2 Antibody (YA1772)
PMS2 Antibody (YA1772) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PMS2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P82549 BRAT1 Antibody (YA2294)
BRAT1 Antibody (YA2294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRAT1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82549A BRAT1 Antibody (YA2294)(PBS only)
BRAT1 Antibody (YA2294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRAT1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84622A DDR2 Antibody (YA4319)(PBS only)
DDR2 Antibody (YA4319) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DDR2.

Host: Mouse; Reactivity: Human, Mouse, Rat, Rabbit

Monoclonal Antibodies Primary Antibodies

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HY-P84716A TNFRSF25 Antibody (YA4413)(PBS only)
TNFRSF25 Antibody (YA4413) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TNFRSF25.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85119 DDR1 Antibody (YA4811)
DDR1 Antibody (YA4811) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DDR1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85120 DDR2 Antibody (YA4812)
DDR2 Antibody (YA4812) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DDR2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85669 XRCC4 Antibody (YA5361)
XRCC4 Antibody (YA5361) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to XRCC4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85792 ERCC1 Antibody (YA5484)
ERCC1 Antibody (YA5484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ERCC1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86288 BRAT1 Antibody (YA5980)
BRAT1 Antibody (YA5980) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRAT1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P87620 RAD52 Antibody (YA7304)
RAD52 Antibody (YA7304) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAD52.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P84535A ATM Antibody (YA4232)(PBS only)
ATM Antibody (YA4232) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ATM.

Host: Mouse; Reactivity: Human, Mouse, Monkey, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P84622 DDR2 Antibody (YA4319)
DDR2 Antibody (YA4319) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DDR2.

Host: Mouse; Reactivity: Human, Mouse, Rat, Rabbit

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P85049 ATM Antibody (YA4741)
ATM Antibody (YA4741) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ATM.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P87024 Phospho-ATR (T1989) Antibody (YA6717)
Phospho-ATR (T1989) Antibody (YA6717) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ATR (T1989).

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P87024A Phospho-ATR (T1989) Antibody (YA6717)(PBS only)
Phospho-ATR (T1989) Antibody (YA6717) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ATR (T1989).

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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Keywords

DDR | ATM | ATR | Wee1 | DNA Repair