1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. 1-Hydroxyanthraquinone

1-Hydroxyanthraquinone 

Cat. No.: HY-W000838
Handling Instructions

1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect.

For research use only. We do not sell to patients.

1-Hydroxyanthraquinone Chemical Structure

1-Hydroxyanthraquinone Chemical Structure

CAS No. : 129-43-1

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Description

1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].

In Vivo

1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Thirty rats[1].
Dosage: 1% HA in diet.
Administration: Diet.
Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment.
A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.
Seven animals of the group died spontaneously or were sacrificed upon becoming moribund between 335 and 462 days.
A total of 21 rats of group 1 survived until the end of experiment (mean value of total intake of HA/rat was 76.8 g).
Molecular Weight

224.21

Formula

C₁₄H₈O₃

CAS No.

129-43-1

SMILES

OC1=CC=CC2=C1C(C3=CC=CC=C3C2=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

1-HydroxyanthraquinoneDNA/RNA SynthesiscarcinogenictumorDNArepairpneumoniaInhibitorinhibitorinhibit

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