TEM8/ANTXR1 Protein, Human (HEK293, Fc)

TEM8/ANTXR1 Protein, multifunctional in cell attachment and migration, interacts with extracellular matrix proteins and the actin cytoskeleton. This engagement mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeleton reorganization and cell spreading, crucial for cellular architecture and motility. TEM8/ANTXR1 also contributes to the angiogenic response in endothelial cells, emphasizing its role in vascular development. In microbial infections, it acts as a receptor for Bacillus anthracis protective antigen (PA), showcasing its dual function in cellular processes and host-pathogen interactions. TEM8/ANTXR1 Protein, Human (HEK293, Fc) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TEM8/ANTXR1 Protein, Human (HEK293, Fc) is 321 a.a., with molecular weight of ~69 kDa.

TEM8/ANTXR1, a multifaceted protein, actively participates in cell attachment and migration. It engages with both extracellular matrix proteins and the actin cytoskeleton, mediating cell adhesion to type 1 collagen and gelatin. This interaction facilitates the reorganization of the actin cytoskeleton and promotes cell spreading, underscoring its crucial role in cellular architecture and motility. Additionally, TEM8/ANTXR1 contributes to the angiogenic response of cultured umbilical vein endothelial cells, emphasizing its involvement in vascular development. Notably, in microbial infection scenarios, TEM8/ANTXR1 serves as a receptor for the protective antigen (PA) of Bacillus anthracis, highlighting its dual role in cellular processes and host-pathogen interactions.

Human

HEK293

C-hFc

Q9H6X2 (M1-S321)

84168  [NCBI]

Approximately 69 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.