TEM8/ANTXR1 Protein, Human (HEK293, Fc)

The TEM8/ANTXR1 protein is multifunctional in cell attachment and migration, interacting with extracellular matrix proteins and the actin cytoskeleton. This binding mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeletal reorganization and cell spreading, which is critical for cell structure and movement. TEM8/ANTXR1 Protein, Human (HEK293, Fc) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293 , with C-hFc labeled tag.

TEM8/ANTXR1, a multifaceted protein, actively participates in cell attachment and migration. It engages with both extracellular matrix proteins and the actin cytoskeleton, mediating cell adhesion to type 1 collagen and gelatin. This interaction facilitates the reorganization of the actin cytoskeleton and promotes cell spreading, underscoring its crucial role in cellular architecture and motility. Additionally, TEM8/ANTXR1 contributes to the angiogenic response of cultured umbilical vein endothelial cells, emphasizing its involvement in vascular development. Notably, in microbial infection scenarios, TEM8/ANTXR1 serves as a receptor for the protective antigen (PA) of Bacillus anthracis, highlighting its dual role in cellular processes and host-pathogen interactions.

Human

HEK293

C-hFc

Q9H6X2-1 (E33-S321)

84168  [NCBI]

Extracellular Domain

EDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGS

Approximately 69 kDa,based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.