ANTXR1 - ANTXR cell adhesion molecule 1 Gene

Also Known as ATR; GAPO; TEM8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84168

About ANTXR1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,013,144-69,249,327 (from NCBI)

This gene has 11 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in gall bladder (RPKM 37.4), ovary (RPKM 30.6) and 21 other tissues.

Summary

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal Cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the Other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

ANTXR1 Products (4)

mRNA Protein Name
NM_001410840.1 NP_001397769.1 anthrax toxin receptor 1 isoform 4 precursor
NM_018153.3 NP_060623.2 anthrax toxin receptor 1 isoform 3 precursor
NM_032208.3 NP_115584.1 anthrax toxin receptor 1 isoform 1 precursor
NM_053034.2 NP_444262.1 anthrax toxin receptor 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
16762926 GOA
enables collagen binding IDA
IDA: Inferred from direct assay
16762926 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14507921 GOA
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
16762926 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
16762926 GOA
involved in substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
16762926 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21129411 GOA
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
21129411 GOA
located in filopodium membrane IDA
IDA: Inferred from direct assay
16762926 GOA
located in lamellipodium membrane IDA
IDA: Inferred from direct assay
16762926 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANTXR1 Protein Structure

VWA

VWA: von Willebrand factor type A domain (44 - 203)

Anth_Ig

Anth_Ig: Anthrax receptor extracellular domain (216 - 320)

Ant_C

Ant_C: Anthrax receptor C-terminus region (396 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 564 a.a.
Protein Preferred Names Protein Names

anthrax toxin receptor 1

  • 2310008J16Rik

Recombinant ANTXR1 Proteins

Cat. No. Product Name Accession Purity
HY-P77226 TEM8/ANTXR1 Protein, Human (HEK293, Fc) Q9H6X2-1 (E33-S321) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gapo Syndrome

  • GAPOS

  • Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy

  • Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome

  • Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy
Hemangioma, Capillary Infantile

  • HCI

  • Capillary Infantile Hemangioma

  • Hemangioma, Hereditary Capillary

  • Hemangioma, Capillary Infantile, Susceptibility To

  • Hemangioma, Capillary Infantile, Somatic

  • Hemangioma Hereditary Capillary
Anthrax Disease

  • Anthrax

  • Ragpicker'S Disease

  • Black Baine

  • Malignant Edema

  • Malignant Pustule

  • Siberian Plague

  • Wool Sorter'S Disease

  • Gas Gangrene

  • Cutaneous Anthrax

  • Anthrax Infection

  • Splenic Fever
Hemangioma

  • Hemangiomas
Hyaline Fibromatosis Syndrome

  • Juvenile Hyaline Fibromatosis

  • Inherited Systemic Hyalinosis

  • Puretic Syndrome

  • Infantile Systemic Hyalinosis

  • HFS

  • Hyalinosis, Systemic

  • Systemic Hyalinosis

  • Molluscum Fibrosum

  • Murray Syndrome

  • Murray-Puretic-Drescher Syndrome

  • Ish

  • Jhf

  • Fibromatosis, Juvenile Hyaline

  • Hyalinosis, Systemic Infantile

  • Fibromatosis, Hyaline Syndrome

  • Neurofibromatosis 1
Cutaneous Anthrax

  • Anthrax, Skin Type

  • Skin Anthrax
Inhalation Anthrax

  • Pulmonary Anthrax

  • Respiratory Anthrax

  • Inhalational Anthrax

  • Wool-Sorters' Disease

  • Woolsorters' Disease

  • Inhalation Anthrax Disease

  • Respiratory Anthrax Disease
Gastrointestinal Anthrax
Oropharyngeal Anthrax
Gingival Hypertrophy

  • Hypertrophy Of Gingivae
Capillary Hemangioma

  • Infantile Hemangioma

  • Strawberry Nevus Of Skin

  • Cellular Hemangioma Of Infancy

  • Congenital Vascular Hamartoma

  • Congenital Vascular Naevus

  • Juvenile Hemangioma

  • Strawberry Haemangioma

  • Strawberry Nevus

  • Hemangioma Capillary

  • Hemangioma, Capillary

  • Hemangioma, Cavernous
Bardet-Biedl Syndrome 2

  • BBS2

  • Bardet-Biedl Syndrome

  • Bardet-Biedl Syndrome, Type 2

  • Bbs
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Capillary Disease

  • Disease Of Capillaries
Robinow Syndrome, Autosomal Recessive 1

  • Robinow Syndrome, Autosomal Recessive

  • Autosomal Recessive Robinow Syndrome

  • Covesdem Syndrome

  • RRS1

  • Costovertebral Segmentation Defect-Mesomelia Syndrome

  • Rrs

  • Costovertebral Segmentation Defect With Mesomelia, Formerly

  • Covesdem Syndrome, Formerly

  • Costovertebral Segmentation Defect With Mesomelia

  • Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

  • Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly

  • Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

  • Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly

  • Robinow, Autosomal Recessive Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183806 ANTXR1-IN-1 Inducer / Unkown
HY-RS00755 ANTXR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18085 Antxr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24559 Antxr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992306 Anti-TEM8 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ANTXR1 VGNC VGNC:37935
Rattus norvegicus ANTXR1 RGD RGD:1307144
Macaca mulatta ANTXR1 VGNC VGNC:69873
Felis catus ANTXR1 VGNC VGNC:59837
Bos taurus ANTXR1 VGNC VGNC:25961
Mus musculus ANTXR1 MGD MGI:1916788
Others ANTXR1 NCBI