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    PI3K/Akt/mTOR
  2. ATM/ATR
  3. ATR inhibitor 2

ATR inhibitor 2 

Cat. No.: HY-136270 Purity: 99.66%
Handling Instructions

ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity.

For research use only. We do not sell to patients.

ATR inhibitor 2 Chemical Structure

ATR inhibitor 2 Chemical Structure

CAS No. : 1613191-99-3

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5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
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Description

ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].

IC50 & Target[1]

ATR

<150 pM (Ki)

In Vivo

In monotherapy efficacy studies ATR inhibitor 2 shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT). In combination with PARP inhibitors, tumor regression could be observed in triple-negative breast cancer xenograft models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

541.55

Formula

C₂₅H₂₉F₂N₉O₃

CAS No.

1613191-99-3

SMILES

O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5CCN(C6COC6)CC5)=O)CC4)C(F)=CN=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (46.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8466 mL 9.2328 mL 18.4655 mL
5 mM 0.3693 mL 1.8466 mL 3.6931 mL
10 mM 0.1847 mL 0.9233 mL 1.8466 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (3.84 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

ATR inhibitor 2ATR inhibitor2ATR inhibitor-2ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedATP-competitiveoralphosphorylationCHK1DNAdamagetriple-negativebreastcancerInhibitorinhibitorinhibit

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Product Name:
ATR inhibitor 2
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HY-136270
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