1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR
  3. ATR inhibitor 2

ATR inhibitor 2 

Cat. No.: HY-136270
Handling Instructions

ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity.

For research use only. We do not sell to patients.

ATR inhibitor 2 Chemical Structure

ATR inhibitor 2 Chemical Structure

CAS No. : 1613191-99-3

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Description

ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].

IC50 & Target[1]

ATR

<150 pM (Ki)

In Vivo

In monotherapy efficacy studies ATR inhibitor 2 (VX-970, M6620) shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT). In combination with PARP inhibitors, tumor regression could be observed in triple-negative breast cancer xenograft models[1].

Molecular Weight

541.55

Formula

C₂₅H₂₉F₂N₉O₃

CAS No.

1613191-99-3

SMILES

O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5CCN(C6COC6)CC5)=O)CC4)C(F)=CN=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ATR inhibitor 2ATR inhibitor2ATR inhibitor-2ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedATP-competitiveoralphosphorylationCHK1DNAdamagetriple-negativebreastcancerInhibitorinhibitorinhibit

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ATR inhibitor 2
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HY-136270
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