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KU-55933

66 Cited Publications
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Based on 66 publication(s) in Google Scholar

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

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  • Purity: 99.92%
  • CAS No.: 587871-26-9
  • 화학식: C21H17NO3S2
  • 분자량:395.49
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • KU-55933 Chemical Structure
    KU-55933 Chemical Structure
  • Experimental Validation Results for KU-55933
  • Experimental Validation Results for KU-55933
  • Experimental Validation Results for KU-55933
  • Experimental Validation Results for KU-55933
  • Experimental Validation Results for KU-55933
  • Experimental Validation Results for KU-55933
  • Experimental Validation Results for KU-55933
CAS No.: 587871-26-9
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  • KU-55933 Chemical Structure
    KU-55933 Chemical Structure
    1/16
  • 1/16

    KU-55933 purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jun 26;188(13):3405-3421.e27. [Abstract]

    Customer Validation
     Representative metaphase FISH images for MYC probes from COLO320DM cells treated with 5 μM KU55933 (ATMi), 0.2 μM AZD7762 (CHKi), and DMSO (no inhibitor) for 24 h. Scale bar, 10 μm.

  • 1/16

    KU-55933 purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jun 26;188(13):3405-3421.e27. [Abstract]

    Customer Validation
     Dose-response curves showing increased sensitivity to ATMi (KU55933, 0.01-100 μM; 48 h) in ecDNA+ versus ecDNA−cells. Mean values ± SEM are presented.

  • 1/16

    KU-55933 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Jun 2;82(11):2032-2049.e7. [Abstract]

    Customer Validation
     Immunofluoscence assay showing the localization of endogenous PARP1 in HeLa cells left uninfected or infected with HSV-1 at MOI 1 for 4 h in the presence of DMSO, ATR inhibitor VE821 (10 μM), ATM inhibitor KU55933 (10 μM) or DNA-PK inhibitor NU-7026 (10 μM), respectively.

  • 1/16

    KU-55933 purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2020 Sep 18;48(16):9109-9123. [Abstract]

    Customer Validation
     Western blotting of p-ATR, ATR, p-ATM, ATM, p-CHK1, CHK1 and p-CDC2 in A549 cells treated with siCtrl or siNRF2, pretreated with 10 μM VE-821 or 20 μM KU-55933 for 2 h, 5 mM NAC for 1 h, and exposed to 8 Gy Cs137 γ-rays.

  • 1/16

    KU-55933 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]

    Customer Validation
     IP assays using anti-PRMT5 antibody were performed in indicated cells treated with CPT (10 μM, 1 h) with or without the ATM inhibitor KU55933 (10 μM, 1 h) pretreatment, and IB analysis of the expression of JDP2 and PRMT5.

  • 1/16

    KU-55933 purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2018 Jul:238:1048-1055. [Abstract]

    Customer Validation
     Time-effects of endosulfan on DNA damage and repair related genes. (AeD) Relative mRNA expression levels of ATM (A), BRCA1 (B), BRCA2 (C) and FANCD2 (D) are measured by qRT-PCR after endosulfan exposure (75 μM, for 12, 24 and 48 h) in the absence and presence of KU-55933.

  • 1/16

    KU-55933 purchased from MedChemExpress. Usage Cited in: Front Oncol. 2017 May 19:7:98. [Abstract]

    Customer Validation
     ATM inhibition by treatment with KU-55933 (10 µM) strongly reduces HR efficiency in JJN3-HR and U266-HR, although cells are still able to perform HR to some extent.

  • KU-55933