1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR
  3. BAY-1895344

BAY-1895344 

Cat. No.: HY-101566 Purity: 99.91%
Handling Instructions

BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.

For research use only. We do not sell to patients.

BAY-1895344 Chemical Structure

BAY-1895344 Chemical Structure

CAS No. : 1876467-74-1

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Description

BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].

IC50 & Target[1]

ATR

7 nM (IC50)

In Vitro

BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1].
BAY-1895344 potently suppresses hydroxyurea-induced H2AX phosphorylation (IC50, 36 nM)[1].

In Vivo

BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2].

Clinical Trial
Molecular Weight

375.43

Formula

C₂₀H₂₁N₇O

CAS No.

1876467-74-1

SMILES

CN1N=CC=C1C2=CC(N3[[email protected]](C)COCC3)=NC4=C(C5=NNC=C5)N=CC=C24

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.4 mg/mL (14.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6636 mL 13.3181 mL 26.6361 mL
5 mM 0.5327 mL 2.6636 mL 5.3272 mL
10 mM 0.2664 mL 1.3318 mL 2.6636 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BAY-1895344BAY1895344BAY 1895344ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedInhibitorinhibitorinhibit

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BAY-1895344
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HY-101566
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