1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR

BAY-1895344 

Cat. No.: HY-101566
Handling Instructions

BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.

For research use only. We do not sell to patients.

BAY-1895344 Chemical Structure

BAY-1895344 Chemical Structure

CAS No. : 1876467-74-1

Size Price Stock
5 mg USD 120 Get quote
10 mg USD 180 Get quote
25 mg USD 390 Get quote
50 mg USD 550 Get quote
100 mg USD 850 Get quote

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Other In-stock Forms of BAY-1895344:

Other Forms of BAY-1895344:

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].

IC50 & Target[1]

ATR

7 nM (IC50)

In Vitro

BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1].
BAY-1895344 potently suppresses hydroxyurea-induced H2AX phosphorylation (IC50, 36 nM)[1].

In Vivo

BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6636 mL 13.3181 mL 26.6361 mL
5 mM 0.5327 mL 2.6636 mL 5.3272 mL
10 mM 0.2664 mL 1.3318 mL 2.6636 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

375.43

Formula

C₂₀H₂₁N₇O

CAS No.

1876467-74-1

SMILES

CN1N=CC=C1C2=CC(N3[[email protected]](C)COCC3)=NC4=C(C5=NNC=C5)N=CC=C24

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BAY-1895344
Cat. No.:
HY-101566
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BAY-1895344

Cat. No.: HY-101566