2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. Elimusertib-d3

Elimusertib-d3  (Synonyms: BAY 1895344-d3)

Cat. No.: HY-101566S Purity: 98.94%
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Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity.

For research use only. We do not sell to patients.

Elimusertib-d<sub>3</sub> Chemical Structure

Elimusertib-d3 Chemical Structure

Size Price Stock Quantity
1 mg USD 400 In-stock
5 mg USD 1200 In-stock
10 mg USD 2100 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Elimusertib-d3 Related Antibodies

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Description

Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity[1].

Molecular Weight

378.45

Formula

C20H18D3N7O
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@H]1N(C2=CC(C3=CC=NN3C([2H])([2H])[2H])=C(C=CN=C4C5=CC=NN5)C4=N2)CCOC1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (264.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6424 mL 13.2118 mL 26.4236 mL
5 mM 0.5285 mL 2.6424 mL 5.2847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6424 mL 13.2118 mL 26.4236 mL 66.0589 mL
5 mM 0.5285 mL 2.6424 mL 5.2847 mL 13.2118 mL
10 mM 0.2642 mL 1.3212 mL 2.6424 mL 6.6059 mL
15 mM 0.1762 mL 0.8808 mL 1.7616 mL 4.4039 mL
20 mM 0.1321 mL 0.6606 mL 1.3212 mL 3.3029 mL
25 mM 0.1057 mL 0.5285 mL 1.0569 mL 2.6424 mL
30 mM 0.0881 mL 0.4404 mL 0.8808 mL 2.2020 mL
40 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6515 mL
50 mM 0.0528 mL 0.2642 mL 0.5285 mL 1.3212 mL
60 mM 0.0440 mL 0.2202 mL 0.4404 mL 1.1010 mL
80 mM 0.0330 mL 0.1651 mL 0.3303 mL 0.8257 mL
100 mM 0.0264 mL 0.1321 mL 0.2642 mL 0.6606 mL
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Elimusertib-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elimusertib-d3BAY 1895344-d3ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedOrallyATRanti-tumorInhibitorinhibitorinhibit

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