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  3. Elimusertib hydrochloride

Elimusertib hydrochloride (Synonyms: BAY 1895344 hydrochloride)

Cat. No.: HY-101566A Purity: 99.84%
Handling Instructions

Elimusertib (BAY 1895344) hydrochloride is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.

For research use only. We do not sell to patients.

Elimusertib hydrochloride Chemical Structure

Elimusertib hydrochloride Chemical Structure

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
2 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Elimusertib (BAY 1895344) hydrochloride is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].

IC50 & Target[1]

ATR

7 nM (IC50)

In Vitro

Elimusertib (BAY 1895344) potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1].
Elimusertib (BAY 1895344) potently suppresses NSC-32065-induced H2AX phosphorylation (IC50, 36 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Elimusertib (BAY 1895344) shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

411.89

Formula

C₂₀H₂₂ClN₇O

SMILES

CN1N=CC=C1C2=C(C=CN=C3C4=CC=NN4)C3=NC(N5[[email protected]](C)COCC5)=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 54 mg/mL (131.10 mM; Need ultrasonic and warming)

H2O : 50 mg/mL (121.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4278 mL 12.1392 mL 24.2783 mL
5 mM 0.4856 mL 2.4278 mL 4.8557 mL
10 mM 0.2428 mL 1.2139 mL 2.4278 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (242.78 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.84%

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Keywords:

ElimusertibBAY 1895344BAY1895344BAY-1895344ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedInhibitorinhibitorinhibit

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Product Name:
Elimusertib hydrochloride
Cat. No.:
HY-101566A
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