Cistanoside C
Cistanoside C is a phenylpropanoid glycoside with free radical scavenging, DNA repair and DNA minor groove binding activities. Cistanoside C scavenges hydrated electrons and hydroxyl radicals. Cistanoside C inhibits the proliferation of cancer cells. Cistanoside C can be used in research related to leukemia, liver cancer, lung adenocarcinoma and gastric adenocarcinoma.
For research use only. We do not sell to patients.
- CAS No.: 94492-22-5
- Formula: C30H38O15
- Molecular Weight:638.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Cistanoside C (0.02-0.1 mM; 5 μs post electron pulse irradiation) acts as an effective hydrated electron scavenger in cell-free nitrogen-saturated aqueous solutions[2].
Cistanoside C (0.05 mM) potently repairs dGMP and dAMP radicals damaged by hydroxyl radicals, and also scavenges hydroxyl radicals[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 94492-22-5
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Molecular Weight 638.61
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Formula C30H38O15
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SMILES
OC(C=C1/C=C/C(O[C@H]([C@H](O[C@H]([C@@H]2O)OCCC3=CC(OC)=C(C=C3)O)CO)[C@@H]2O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)=O)=C(C=C1)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
[1]. Delalande O, et al. Docking study of cistanoside C to telomeric DNA fragment. SAR QSAR Environ Res. 2002 Dec;13(7-8):675-88. [Content Brief]
[3]. Sperandio O, et al. Theoretical study of fast repair of DNA damage by cistanoside C and analogs: mechanism and docking. SAR QSAR Environ Res. 2002 Mar;13(2):243-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cistanoside C Related Classifications
HY-N19343 Related Classifications
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