Collagen (bovine skin) 

Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development^[1][2].

Collagen (bovine skin) in vitro reconstituted pepsinized bovine skin collagen forms sparse 3D lattices with larger pores (median pore diameter 3.2 μm), while non-pepsinized bovine skin collagen forms dense 3D lattices with smaller pores (median pore diameter 1.7 μm), both displaying homogeneous pore size distributions^[1].
Collagen (bovine skin) (1-2 mg/mL) forms 3D matrices with large pores that facilitate primary fibroblast migration through the gel layers, when used at a concentration of 1-2 mg/mL for gel formation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9064-67-9

Solid

Off-white to light yellow

[Collagen (bovine skin)]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wolf K, et al. Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol. 2009;20(8):931-941.

  [2]. Kanta J, et al. Collagen matrix as a tool in studying fibroblastic cell behavior. Cell Adh Migr. 2015;9(4):308-316.