DDR2
null Encoded by the DDR2 gene, this discoidin domain receptor is the second collagen-binding receptor tyrosine kinase and the close paralog of DDR1. DDR2 shares the discoidin collagen-recognition module and kinase domain but is expressed chiefly in mesenchymal tissues such as cartilage, bone, heart, and fibroblasts rather than in epithelium. Binding of fibrillar collagen type I triggers delayed, sustained kinase activation that modulates matrix metalloproteinase expression, cell spreading, and proliferation. DDR2 signaling supports chondrocyte and osteoblast function, and missense mutations in its kinase domain cause spondylo-meta-epiphyseal dysplasia with joint laxity. Elevated DDR2 activity has also been linked to tissue fibrosis and to the invasive behavior of certain carcinomas.
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DDR2 組換えタンパク質 (10)
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Inhibitors & Agonists (17)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
