DDR2 Protein, Mouse (HEK293, His)
Based on 1 Customer Validation
The DDR2 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that critically regulates cell differentiation, extracellular matrix remodeling, migration, and proliferation.DDR2 is crucial for bone development.It affects osteoblast differentiation and chondrocyte maturation through the MAP kinase signaling pathway and activates the transcription factor RUNX2.DDR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The DDR2 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that critically regulates cell differentiation, extracellular matrix remodeling, migration, and proliferation.DDR2 is crucial for bone development.It affects osteoblast differentiation and chondrocyte maturation through the MAP kinase signaling pathway and activates the transcription factor RUNX2.DDR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR2 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
DDR2 protein serves as a tyrosine kinase functioning as a cell surface receptor for fibrillar collagen, pivotal in regulating cell differentiation, extracellular matrix remodeling, cell migration, and cell proliferation. Its role is essential for normal bone development, influencing osteoblast differentiation and chondrocyte maturation through a signaling pathway involving MAP kinases, ultimately activating the transcription factor RUNX2. DDR2 also plays a crucial part in extracellular matrix remodeling by up-regulating collagenases MMP1, MMP2, and MMP13, facilitating cell migration and promoting tumor cell invasion. Additionally, DDR2 promotes fibroblast migration and proliferation, contributing significantly to the process of cutaneous wound healing. The multifaceted functions of DDR2 underscore its importance in diverse cellular processes associated with tissue development, maintenance, and repair.
Verified Bioactivity
This product does not contain protein kinase domain.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-6*His
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Accession
Q62371 (Q24-R399)
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Molecular Construction
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N-term
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DDR2 (Q24-R399)
Accession # Q62371 -
6*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
DDR2; Discoidin Domain Receptor 2; Prev. TYRO10; Neurotrophic Tyrosine Kinase Receptor Related 3; Prev. NTRKR3; Migration-Inducing Gene 16 Protein; TKT; Cell Migration-Inducing Protein 20; Discoidin Domain-Containing Receptor Tyrosine Kinase 2; Hydroxyary
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AA Sequence
QVNPAICRYPLGMSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTYDPMLKVDDSNTR
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Predicted Molecular Mass
43.5 kDa
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Molecular Weight
Approximately 60-75 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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