2. Gene
  3. Ddr2 - discoidin domain receptor family, member 2 Gene

Ddr2 - discoidin domain receptor family, member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ntrkr3; tyro10

Gene ID: 18214 | Gene type: protein coding

About Ddr2

Chromosome 1: 169,799,876-169,938,331 reverse strand.GRCm39:CM000994.3

This gene has 6 transcripts (splice variants), 263 orthologues, 53 paralogues and is associated with 49 phenotypes. Biased expression in bladder adult (RPKM 28.6), limb E14.5 (RPKM 18.7) and 13 other tissues.

Summary

Enables collagen binding activity and protein tyrosine kinase collagen receptor activity. Involved in several processes, including chondrocyte proliferation; collagen fibril organization; and collagen-activated tyrosine kinase receptor signaling pathway. Acts upstream of or within positive regulation of cell population proliferation; protein autophosphorylation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in actin Cytoskeleton and apical plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in alimentary system; central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ddr2 Products(1)

mRNA Protein Name
NM_022563.2 NP_072075.2 discoidin domain-containing receptor 2 precursor

Ddr2 Protein Structure

FA58C

FA58C: cd00057 (31 - 183)

PKc_like

PKc_like: cl21453 (556 - 849)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 854 a.a.
Protein Preferred Names Protein Names

discoidin domain-containing receptor 2

CD167 antigen-like family member B

discoidin domain receptor 2

neurotrophic tyrosine kinase, receptor-related 3

receptor protein-tyrosine kinase TKT

tyrosine-protein kinase TYRO10

Recombinant Ddr2 Proteins

Cat. No. Product Name Accession Purity
HY-P72673 DDR2 Protein, Mouse (HEK293, His) Q62371 (Q24-R399) ≥95%
HY-P74520 TGFBR3/TGF-beta RIII Protein, Mouse (763a.a) NP_035708.2 (G23-T785) ≥95%
HY-P77349 DDR2 Protein, Mouse (399a.a, HEK293, His) Q62371 (M1-R399) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16961 Sitravatinib Inhibitor 99.59% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114169 WRG-28 Inhibitor 99.34% Unkown
HY-135401 VU6015929 Inhibitor 99.26% Unkown
HY-114311 FGFR1/DDR2 inhibitor 1 Inhibitor 98.26% Unkown
HY-114173 DDR1-IN-4 Inhibitor 98.01% Unkown
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-156552 DDR1/2 inhibitor-2 Inhibitor / Unkown
HY-162102 DDR1-IN-8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddr2 NCBI NCBI:4921
Rattus norvegicus Ddr2 NCBI NCBI:685781
Macaca mulatta Ddr2 NCBI NCBI:720124