Ddr2 - discoidin domain receptor family, member 2 Gene

Also Known as Ntrkr3; tyro10

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18214

About Ddr2

Chromosome 1: 169,799,876-169,938,331 reverse strand.GRCm39:CM000994.3

This gene has 6 transcripts (splice variants), 263 orthologues, 53 paralogues and is associated with 49 phenotypes. Biased expression in bladder adult (RPKM 28.6), limb E14.5 (RPKM 18.7) and 13 other tissues.

Summary

Enables Collagen binding activity and protein tyrosine kinase Collagen receptor activity. Involved in several processes, including chondrocyte proliferation; Collagen fibril organization; and collagen-activated tyrosine kinase receptor signaling pathway. Acts upstream of or within positive regulation of cell population proliferation; protein autophosphorylation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in actin Cytoskeleton and apical plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in alimentary system; central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ddr2 Products (1)

mRNA	Protein	Name
NM_022563.2	NP_072075.2	discoidin domain-containing receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IDA IDA: Inferred from direct assay	16806867	MGI
enables protein tyrosine kinase collagen receptor activity	IDA IDA: Inferred from direct assay	11723120	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in biomineral tissue development	IMP IMP: Inferred from mutant phenotype	19900459	MGI
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	11723120	MGI
involved in chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	11375938	MGI
involved in collagen fibril organization	IMP IMP: Inferred from mutant phenotype	19900459	MGI
involved in collagen-activated tyrosine kinase receptor signaling pathway	IDA IDA: Inferred from direct assay	11723120	MGI
involved in endochondral bone growth	IMP IMP: Inferred from mutant phenotype	11375938	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11723120	MGI
involved in positive regulation of extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	11723120	MGI
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	11723120	MGI
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	11375938	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	16806867	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ddr2 Protein Structure

FA58C

PKc_like

0
200
400
600
800
854 a.a.

Protein Preferred Names	Protein Names
discoidin domain-containing receptor 2	CD167 antigen-like family member B discoidin domain receptor 2 neurotrophic tyrosine kinase, receptor-related 3 receptor protein-tyrosine kinase TKT tyrosine-protein kinase TYRO10

Recombinant Ddr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72673	DDR2 Protein, Mouse (HEK293, His)	Q62371 (Q24-R399)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114169	WRG-28	Inhibitor	99.76%	Unkown
HY-135401	VU6015929	Inhibitor	99.50%	Unkown
HY-114173	DDR1-IN-4	Inhibitor	98.19%	Unkown
HY-NP175	Collagen (bovine skin)	Ligand	/	Unkown
HY-114311	FGFR1/DDR2 inhibitor 1	Inhibitor	98.26%	Unkown
HY-156552	DDR1/2 inhibitor-2	Inhibitor	99.73%	Unkown
HY-13979A	DDR1-IN-1 dihydrochloride	Inhibitor	98.92%	Unkown
HY-167208	SR-302	Inhibitor	98.51%	Unkown
HY-175202	CIDD-8633	Inhibitor	/	Unkown
HY-16961A	Sitravatinib malate	Inhibitor	/	Unkown
HY-176849	DDR2-IN-2	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-181839	DDR1/2 IN-4	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown
HY-122848	DDR1/2 inhibitor-3	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992066	Anti-Mouse DDR2 Antibody (DAB0065)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddr2	NCBI	NCBI:4921