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Art. -Nr.: HY-175202

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CIDD-8633

CIDD-8633 is a potent DDR2 inhibitor with an IC₅₀ of 6.105 μM. CIDD-8633 inhibits cell migration and halts the cell cycle and induces apoptosis, significantly suppressing pancreatic ductal adenocarcinoma (PDAC) tumor growth. CIDD-8633 can be used for the study of pancreatic cancer such as PDAC.

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CAS. Nr.: 1428356-95-9
Formel: C₂₂H₂₃N₉O₂
Molecular Weight:445.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CIDD-8633 Chemical Structure

CAS. Nr.: 1428356-95-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

DDR2

6.105 μM (IC₅₀)

Caspase 3

IL-6

Alle Discoidin Domain Receptor Isoform-spezifische Produkte anzeigen :

DDR1
DDR2

Alle Caspase Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

CIDD-8633 (4-5.5 μM, 7-10 days) inhibits the long-term clonal formation ability of AsPC1 and MIA-PaCa-2 cells^[1].
CIDD-8633 (4-6 μM, 72 h) significantly reduces the levels of phosphorylated-DDR2 and its downstream effector phospho-ERK in AsPC1 and MIA-PaCa-2 cells^[1].
CIDD-8633 (1.5 μM, 48 h) inhibits the nuclear translocation of the DDR2-ERK signaling pathway and blocks the proliferative signals in AsPC1 and MIA-PaCa-2 cells^[1].
CIDD-8633 (0.1-10 μM, 72 h) significantly reduces the proliferation of MIA-PaCa-2 cells and AsPC-1 with IC₂₅s of 4.0 and 5.5 μM, respectively^[1].
CIDD-8633 (4 μM, 16 h) reduces the migration ability of MIA PaCa-2 cells by inhibiting DDR2^[1].
CIDD-8633 (4-6 μM, 72 h) inhibits the cell cycle progression by blocking the G1/S phase in AsPC1 and MIA-PaCa-2 cells CIDD-8633 (4-6 μM, 72 h) induces apoptosis in AsPC1 and MIA-PaCa-2 cells by activating caspase-3^[1].
CIDD-8633 (6 μM, 48 h) upregulates the genes including CDKN1A, DDIT3, IL-1β, PMAIP1, and CASP4 in AsPC1 and MIA-PaCa-2 cells^[1].
CIDD-8633 (4-10 μM, 72 h) significantly reduces the levels of p-DDR2 and p-ERK, and increases the level of cleaved caspase-3 in AsPC1 and MIA-PaCa-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

AsPC1 and MIA-PaCa-2 cells
Concentration:

1.5 μM
Incubation Time:

48 h
Result:

Localized the phospho-ERK was predominantly in the nucleus of cells.
Resulted in more cytoplasmic localization of phospho-ERK and a marked decrease in its intensity.

Cell Viability Assay^[1]

Cell Line:

GC68, AsPC1, MIA-PaCa-2, Panc02 and KPC cells
Concentration:

0.1, 1 and 10 μM
Incubation Time:

72 h
Result:

Exhibited IC₅₀s of 6.088, 6.284, 5.025, 4.926 and 10.05 μM, respectively.

Cell Migration Assay ^[1]

Cell Line:

AsPC1 and MIA-PaCa-2 cells
Concentration:

6 μM
Incubation Time:

48 h
Result:

Increased the levels of CDKN1A, DDIT3, IL-1β, PMAIP1 and CASP4.

Apoptosis Analysis^[1]

Cell Line:

AsPC1 and MIA-PaCa-2 cells
Concentration:

4 and 6 μM
Incubation Time:

72 h
Result:

Increased the proportion of apoptotic cells by 2 to 3 times.

Cell Cycle Analysis^[1]

Cell Line:

AsPC1 and MIA-PaCa-2 cells
Concentration:

4 and 6 μM
Incubation Time:

72 h
Result:

Increased the proportion of G1 phase cells by 20-30%.

RT-PCR^[1]

Cell Line:

AsPC1 and MIA-PaCa-2 cells
Concentration:

6 μM
Incubation Time:

48 h
Result:

Increased the levels of CDKN1A, DDIT3, IL-1β, PMAIP1 and CASP4.

Western Blot Analysis^[1]

Cell Line:

AsPC1 and MIA-PaCa-2 cells
Concentration:

4 and 6 μM
Incubation Time:

72 h
Result:

Decreased the levels of p-DDR2 and p-ERK.
Increased the level of cleaved caspase-3.

In Vivo

CIDD-8633 (40 mg/kg, i.p., twice a week for 28 days) exerts anti-tumor effects by targeting DDR2 in mouse models established from MIA PaCa-2 cells and Pan02 cells respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MIA PaCa-2 induced PDAC model established in NOD/SCID mice^[1]
Dosage:

40 mg/kg
Administration:

Intraperitoneal injection (i.p.), twice a week for 28 days
Result:

Significant decreased the tumor weight and volume.
Decreased the levels of p-DDR2 and p-ERK.

Animal Model:

Pan02 induced PDAC model established in C57BL/6J mice^[1]
Dosage:

40 mg/kg
Administration:

Intraperitoneal injection (i.p.), twice a week for 28 days
Result:

Delayed the tumor growth.
Decreased the levels of p-DDR2 and p-ERK.

Chemical Information

CAS. Nr. 1428356-95-9
Molecular Weight 445.48
Formel C₂₂H₂₃N₉O₂
SMILES

O=C(NC1=CC=C(NC2=NC(NCC)=NC(C)=C2)C=C1)COC(C=C3)=NN=C3N4C=CC=N4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Do CT, et al. Targeting DDR2 for Treating Pancreatic Cancer. Mol Cancer Ther. 2025 Jun 26. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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CIDD-8633

Alle Discoidin Domain Receptor Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen