country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P992066

Copy Link Print Information

Anti-Mouse DDR2 Antibody (DAB0065)

Anti-Mouse DDR2 Antibody (DAB0065) is a mAb that specifically targets mouse discoidin domain receptor DDR2 without cross-reacting with DDR1. Anti-Mouse DDR2 Antibody (DAB0065) binds to the extracellular domain of native mouse DDR2, induces endocytosis and lysosomal degradation of DDR2, and this process is independent of collagen binding. Anti-Mouse DDR2 Antibody (DAB0065) exhibits significant therapeutic effects in both the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis and the bleomycin (HY-108345)-induced mouse model of pulmonary fibrosis, effectively downregulating the mRNA expression of type I collagen Col1a1 and fibronectin Fn1. Anti-Mouse DDR2 Antibody (DAB0065) can be humanized and has the potential to be developed as a targeted agent for diseases such as idiopathic pulmonary fibrosis and renal fibrosis.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anti-Mouse DDR2 Antibody (DAB0065) Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Anti-Mouse DDR2 Antibody (DAB0065) Product Recommendations:

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Mouse IgG2a kappa

Recommend Isotype Controls

Mouse IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

DDR2

All Discoidin Domain Receptor Isoforms :

DDR1
DDR2

In Vitro

Anti-Mouse DDR2 Antibody (DAB0065) is generated from B cell clones of immunized New Zealand white rabbits and shows no cross-reactivity with the homologous DDR1. Through its heavy and light chain variable regions (VH/VL) and hypervariable regions (HVR), Anti-Mouse DDR2 Antibody (DAB0065) specifically binds to a conformational epitope in the extracellular discoidin domain (DS domain) of DDR2, which involves 19 key amino acid residues. This binding induces collagen-independent endocytosis and lysosomal degradation of DDR2^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse DDR2 Antibody (DAB0065) significantly reduces the mRNA level of renal type I collagen α1 (Col1a1) in the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis^[1]^[2].
Anti-Mouse DDR2 Antibody (DAB0065) significantly downregulates the mRNA expressions of Col1a1 and fibronectin Fn1 in lung tissues simultaneously in bleomycin (BLM)-induced mouse pulmonary fibrosis models. Its therapeutic efficacy is superior to that of DAB0045 (HY-P992066), DAB0048 and DAB0069 (HY-P992066) in the same group, and is comparable to that of the anti-mature TGF-β antibody GC1008 (HY-P99020)^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

18214 [NCBI]

Accession

Q62371

Target

DDR2

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay, Research in vivo

Chemical Information

SMILES

[Anti-Mouse DDR2 Antibody (DAB0065)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Noriyuki Takahashi, et al. Anti-ddr2 antibodies and uses thereof. EP4155321A1. 2022-06-02.

[2]. Noriyuki Takahashi, et al. Anti-ddr2 antibodies and uses thereof. US20240270853A1/WO2022255440A1. 2022-06-02.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Anti-Mouse DDR2 Antibody (DAB0065)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

All Discoidin Domain Receptor Isoforms