Anti-Mouse DDR2 Antibody (DAB0065) 

Anti-Mouse DDR2 Antibody (DAB0065) is a mAb that specifically targets mouse discoidin domain receptor DDR2 without cross-reacting with DDR1. Anti-Mouse DDR2 Antibody (DAB0065) binds to the extracellular domain of native mouse DDR2, induces endocytosis and lysosomal degradation of DDR2, and this process is independent of collagen binding. Anti-Mouse DDR2 Antibody (DAB0065) exhibits significant therapeutic effects in both the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis and the bleomycin (HY-108345)-induced mouse model of pulmonary fibrosis, effectively downregulating the mRNA expression of type I collagen Col1a1 and fibronectin Fn1. Anti-Mouse DDR2 Antibody (DAB0065) can be humanized and has the potential to be developed as a targeted agent for diseases such as idiopathic pulmonary fibrosis and renal fibrosis^[1][2].

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Mouse

Anti-Mouse DDR2 Antibody (DAB0065) is generated from B cell clones of immunized New Zealand white rabbits and shows no cross-reactivity with the homologous DDR1. Through its heavy and light chain variable regions (VH/VL) and hypervariable regions (HVR), Anti-Mouse DDR2 Antibody (DAB0065) specifically binds to a conformational epitope in the extracellular discoidin domain (DS domain) of DDR2, which involves 19 key amino acid residues. This binding induces collagen-independent endocytosis and lysosomal degradation of DDR2^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse DDR2 Antibody (DAB0065) significantly reduces the mRNA level of renal type I collagen α1 (Col1a1) in the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis^[1][2].
Anti-Mouse DDR2 Antibody (DAB0065) significantly downregulates the mRNA expressions of Col1a1 and fibronectin Fn1 in lung tissues simultaneously in bleomycin (BLM)-induced mouse pulmonary fibrosis models. Its therapeutic efficacy is superior to that of DAB0045 (HY-P992066), DAB0048 and DAB0069 (HY-P992066) in the same group, and is comparable to that of the anti-mature TGF-β antibody GC1008 (HY-P99020)^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

18214  [NCBI]

Q62371

DDR2

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

[Anti-Mouse DDR2 Antibody (DAB0065)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Noriyuki Takahashi, et al. Anti-ddr2 antibodies and uses thereof. EP4155321A1. 2022-06-02.

  [2]. Noriyuki Takahashi, et al. Anti-ddr2 antibodies and uses thereof. US20240270853A1/WO2022255440A1. 2022-06-02.